| An analysis of the utility of handheld PET probes for the intraoperative localization of malignant tissue. | |
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MedLine Citation:
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PMID: 21108016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The intraoperative localization of suspicious lesions detected by positron emission tomography (PET) scan remains a challenge. To solve this, two novel probes have been created to accurately detect the (18)F-FDG radiotracer intraoperatively. METHODS: Nude rats were inoculated with mesothelioma. When PET scans detected 10-mm tumors, animals were dissected and the PET probes analyzed the intraoperative radiotracer uptake of these lesions as tumor to background ratio (TBR). RESULTS: The 17 suspicious lesions seen on PET scan were localized intraoperatively (by their high TBR) using the PET probes and found malignant on pathology. Interestingly, smaller tumors not visualized on PET scan were detected intraoperatively by their high TBR and found malignant on pathology. Furthermore, using a TBR threshold as low as 2.0, both gamma (sensitivity, 100%; specificity, 80%; positive predictive value (PPV), 96%; and negative predictive value (NPV), 100%) and beta (sensitivity, 100%; specificity, 60%; PPV, 93%; and NPV, 100%) probes reliably detected suspicious lesions on PET scan imaging. They also showed an excellent area under the curve of 0.9 and 0.97 (95% CI of 0.81-0.99 and 0.93-1.0) for gamma and beta probes, respectively, in the receiver operating characteristic analysis for detecting malignancy. CONCLUSION: This novel tool could be used synergistically with a PET scan imaging to maximize tissue selection intraoperatively. |
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Authors:
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Segundo Jaime González; Lorena González; Joyce Wong; Peter Brader; Maureen Zakowski; Mithat Gönen; Farhad Daghighian; Yuman Fong; Vivian E Strong |
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Publication Detail:
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Type: Journal Article Date: 2010-11-25 |
Journal Detail:
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Title: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract Volume: 15 ISSN: 1873-4626 ISO Abbreviation: J. Gastrointest. Surg. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-09 Completed Date: 2011-06-22 Revised Date: 2012-02-10 |
Medline Journal Info:
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Nlm Unique ID: 9706084 Medline TA: J Gastrointest Surg Country: United States |
Other Details:
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Languages: eng Pagination: 358-66 Citation Subset: IM |
Affiliation:
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Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Area Under Curve Beta Particles Fluorodeoxyglucose F18 / diagnostic use* Intraoperative Care* Mesothelioma / pathology, radionuclide imaging* Neoplasm Transplantation Pleural Neoplasms / pathology, radionuclide imaging* Positron-Emission Tomography / instrumentation*, methods Predictive Value of Tests ROC Curve Radiopharmaceuticals / diagnostic use* Rats Rats, Nude |
| Grant Support | |
ID/Acronym/Agency:
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T32 CA009501-21/CA/NCI NIH HHS; T32 CA009501-22/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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