Document Detail

Analysis of Usnea fasciata crude extracts with antineoplastic activity.
MedLine Citation:
PMID:  7660383     Owner:  NLM     Status:  MEDLINE    
Different fractions, isolated from the lichen Usnea fasciata, were analyzed by PC, TLC, and RP-HPLC. Analysis of the organic phases, mainly containing phenolics, revealed that usnic acid is the main product from secondary metabolites, whereas the polysaccharides isolichenin and raffinose are the most abundant water-soluble carbohydrates. Fractions containing usnic acid, as well as those containing isolichenin, showed moderate activity against sarcoma 180 and Ehrlich tumor cells. High antitumoral activity, near 90% inhibition, was found associated with the fraction containing raffinose.
E C Periera; S C Nascimento; R C Lima; N H Silva; A F Oliveira; E Bandeira; M Boitard; H Beriel; C Vicente; M E Legaz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Tokai journal of experimental and clinical medicine     Volume:  19     ISSN:  0385-0005     ISO Abbreviation:  Tokai J. Exp. Clin. Med.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-10-04     Completed Date:  1995-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704186     Medline TA:  Tokai J Exp Clin Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  47-52     Citation Subset:  IM    
Department of Plant Physiology, Faculty of Biology, Complutense University, Spain.
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MeSH Terms
Antineoplastic Agents, Phytogenic / isolation & purification*,  metabolism
Carbohydrates / isolation & purification,  pharmacology
Carcinoma, Ehrlich Tumor / drug therapy
Lethal Dose 50
Lichens / chemistry*
Sarcoma 180 / drug therapy
Tumor Cells, Cultured
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Carbohydrates

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