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Analysis of TRPV1 gene polymorphisms in Spanish patients with neuropathic pain.
MedLine Citation:
PMID:  22401740     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: The vanilloid receptor TRPV1 is a molecular integrator of painful stimuli. Several recent studies suggest that TRPV1 may play a role in development and maintenance of chronic pain. In an attempt to determine if genotypic variations in TRPV1 gene could be involved in the susceptibility to suffer neuropathic pain we have studied genetic variants of human TRPV1 gene. PATIENTS AND METHODS: We have studied the distribution of Met315Ile and Ile585Val TRPV1 polymorphisms in a total of 440 Caucasian subjects: 232 patients with neuropathic pain and 208 healthy subjects matched by age and sex. The polymorphisms were analyzed with polymerase chain reaction (PCR) using TaqMan probes specific for each allele. RESULTS: Our results show that the distribution of Met315Ile and Ile585Val genotypes and alleles is similar in patients with neuropathic pain and in healthy subjects. However, the Met315Met genotype is more frequent in females diagnosed as suffering neuropathic pain. No differences were observed when we segregate the patients according to visual analogue scale values. CONCLUSIONS: The observation of differences in the distribution of Met315Ile TRPV1 genotypes only in females diagnosed of neuropathic pain suggests that this polymorphism, together with other physiological factors such as sex, may influence individual susceptibility to neuropathic pain.
Authors:
Pilar Armero; Clemente Muriel; Mónica López; Juan Santos; Rogelio González-Sarmiento
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-6
Journal Detail:
Title:  Medicina clinica     Volume:  -     ISSN:  0025-7753     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376377     Medline TA:  Med Clin (Barc)     Country:  -    
Other Details:
Languages:  SPA     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier España, S.L. All rights reserved.
Affiliation:
Cátedra Extraordinaria del Dolor, Fundación Grünenthal-Universidad de Salamanca, Salamanca, España; Unidad de Medicina Molecular, Departamento de Medicina, Universidad de Salamanca, Salamanca, España.
Vernacular Title:
Análisis de polimorfismos del gen TRPV1 en pacientes españoles con dolor neuropático.
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