Document Detail


Analysis of seed loss and pulmonary seed migration in patients treated with virtual needle guidance and robotic seed delivery.
MedLine Citation:
PMID:  20805736     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE AND BACKGROUND: To determine whether automated seed delivery system and real-time intraoperative (IO) virtual needle guidance reduce seed loss and pulmonary seed migration.
PATIENTS AND METHODS: We analyzed 279 patients with low and intermediate risk prostate cancer treated in our institution with radioactive iodine (I-125) permanent seed implants. Loose seeds were exclusively used. To account for lost seeds, pelvic fluoroscopic imaging from 3 different angles was done 30 days after the implant. Posteroanterior and lateral chest x-rays were done when seed loss was confirmed. Patients were compared using the χ test and Fisher exact test.
RESULTS: At least 1 seed was lost in 31.5% of patients with a migration rate of 1.02%; 9.3% of patients had at least 1 seed in the lung with a migration rate of 0.22%. The population was divided into 3 groups according to the order in which they were treated. Seed loss (P=0.02) and pulmonary seed embolization (P=0.008) were significantly lower in the second hundred than in the first hundred patients. No difference was noted between groups 1 and 3 (patient, 201-279). Peri- or extracapsular seed placement was not correlated to seed loss (P=0.780 and P=0.092, respectively). No serious complications from seed migration were reported. Seed loss did not influence dosimetry parameters (V100, V150, and D90).
CONCLUSION: Our pulmonary seed migration and total seed loss rates are comparable to the ones reported in the literature. Virtual needle guidance and automated seed delivery system are in our hand as accurate as the manual technique.
Authors:
Lara Hathout; David Donath; Camille Moumdjian; Audrey Tétreault-Laflamme; Renée Larouche; Dominic Béliveau-Nadeau; Yannick Hervieux; Daniel Taussky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical oncology     Volume:  34     ISSN:  1537-453X     ISO Abbreviation:  Am. J. Clin. Oncol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207754     Medline TA:  Am J Clin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  449-53     Citation Subset:  IM    
Affiliation:
Department of Radiation Oncology, University of Montreal Medical, Centre (CHUM), Montreal, Quebec, Canada.
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