Document Detail


Analysis of reaction products of food contaminants and ingredients: bisphenol A diglycidyl ether (BADGE) in canned foods.
MedLine Citation:
PMID:  20334396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bisphenol A diglycidyl ether (BADGE) is an epoxide that is used as a starting substance in the manufacture of can coatings for food-contact applications. Following migration from the can coating into food, BADGE levels decay and new reaction products are formed by reaction with food ingredients. The significant decay of BADGE was demonstrated by liquid chromatographic (LC) analysis of foodstuffs, that is, tuna, apple puree, and beer, spiked with BADGE before processing and storage. Life-science inspired analytical approaches were successfully applied to study the reactions of BADGE with food ingredients, for example, amino acids and sugars. An improved mass balance of BADGE was achieved by selective detection of reaction products of BADGE with low molecular weight food components, using a successful combination of stable isotopes of BADGE and analysis by LC coupled to fluorescence detection (FLD) and high-resolution mass spectrometric (MS) detection. Furthermore, proteomics approaches showed that BADGE also reacts with peptides (from protein digests in model systems) and with proteins in foods. The predominant reaction center for amino acids, peptides, and proteins was cysteine.
Authors:
Leon Coulier; Emma L Bradley; Richard C Bas; Kitty C M Verhoeckx; Malcolm Driffield; Nick Harmer; Laurence Castle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  58     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4873-82     Citation Subset:  IM    
Affiliation:
TNO Quality of Life, Utrechtseweg, HE Zeist, The Netherlands. leon.coulier@tno.nl
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MeSH Terms
Descriptor/Qualifier:
Epoxy Compounds / analysis*
Food Contamination*
Mass Spectrometry
Spectrometry, Fluorescence
Chemical
Reg. No./Substance:
0/Epoxy Compounds; 1675-54-3/2,2-bis(4-glycidyloxyphenyl)propane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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