| An analysis of prospective risk factors for aortic stiffness in men: 20-year follow-up from the Caerphilly prospective study. | |
| | |
MedLine Citation:
|
PMID: 20530296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Arterial stiffness is an important determinant of cardiovascular risk. The precise risk factors for arterial stiffening remain unclear. We aimed to identify potential risk factors using prospective exposure data from the Caerphilly Prospective Study. Aortic pulse wave velocity and augmentation index were measured in 825 men and related to current (2004) and baseline (1979-1988) anthropometric, hemodynamic, and biochemical factors. The mean age of the men was 74 years, with an average follow-up of 20 years. The only independent baseline predictors of current velocity were pulse pressure (standardized beta-coefficient: 0.58), C-reactive protein (0.35), glucose (0.25), and waist circumference (0.23). The sole baseline predictor of current augmentation index was fibrinogen (0.78). After additional adjustment for the corresponding current risk factor, pulse wave velocity was best related to cumulative exposure to C-reactive protein, whereas augmentation index was most strongly related to current levels. Velocity was also more strongly correlated with baseline levels of triglycerides and smoking but with current waist circumference. The pulse pressure heart rate product assessed over the whole of 20 years was independently correlated with aortic pulse wave velocity but not augmentation index. Other than blood pressure, established cardiovascular risk factors have only a modest effect on aortic stiffness and wave reflection. Inflammation and the level of repetitive cyclic stress are important predictors of aortic stiffness, whereas wave reflection is predicted by acute inflammation only. Adequate control of pulse pressure and heart rate, as well as reducing inflammation, may, in the long-term, retard aortic stiffening, although this remains to be tested directly. |
| | |
Authors:
|
Carmel M McEniery; Michael Spratt; Margaret Munnery; John Yarnell; Gordon D Lowe; Ann Rumley; John Gallacher; Yoav Ben-Shlomo; John R Cockcroft; Ian B Wilkinson |
Related Documents
:
|
8130496 - Non-invasive assessment of cardiovascular mechanics using a new, user-friendly software... 9437586 - Temporal relationships between oxytocin and 13,14-dihydro-15-keto-prostaglandin f2 alph... 8241526 - A comparison between the automatized impedance cardiography and pulsed-wave doppler ech... 18219296 - Effects of reduced cyclic stretch on vascular smooth muscle cell function of pig caroti... 7592226 - Subpleural pulmonary microvascular pressures in the dog lung. 3992046 - Accelerated recovery of ischemic canine myocardium induced by amp. preliminary report. |
Publication Detail:
|
Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-06-07 |
Journal Detail:
|
Title: Hypertension Volume: 56 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-17 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
|
Languages: eng Pagination: 36-43 Citation Subset: IM |
Affiliation:
|
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Box 110, Cambridge CB2 0QQ, UK. cmm41@cam.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aorta / physiology* Cardiovascular Diseases / epidemiology, physiopathology Cross-Sectional Studies Follow-Up Studies Great Britain / epidemiology Heart Rate Humans Incidence Male Middle Aged Prognosis Prospective Studies Pulsatile Flow / physiology* Questionnaires Risk Assessment / methods* Risk Factors Sphygmomanometers Time Factors Vascular Resistance / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
//British Heart Foundation |
| Comments/Corrections | |
Comment In:
|
Hypertension. 2010 Jul;56(1):29-30
[PMID:
20530292
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of Circulating and Local Uteroplacental Angiotensin II in Rat Pregnancy.
Next Document: "The Lower the BP the Better" Paradigm in the Elderly. Vanished by VALISH?