Document Detail


Analysis of the Presence of Cell Proliferation-Related Molecules in the Tgf-β(3) Null Mutant Mouse Palate Reveals Misexpression of EGF and Msx-1.
MedLine Citation:
PMID:  20881363     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The Tgf-β(3) null mutant mouse palate presents several cellular anomalies that lead to the appearance of cleft palate. One of them concerns the cell proliferation of both the palatal medial edge epithelium and mesenchyme. In this work, our aim was to determine whether there was any variation in the presence/distribution of several cell proliferation-related molecules that could be responsible for the cell proliferation defects observed in these palates. Our results showed no difference in the presence of EGF-R, PDGF-A, TGF-β(2), Bmp-2, and Bmp-4, and differences were minimal for FGF-10 and Shh. However, the expression of EGF and Msx-1 changed substantially. The shift of the EGF protein expression was the one that most correlated with that of cell proliferation. This molecule is regulated by TGF-β(3), and experiments blocking its activity in culture suggest that EGF misexpression in the Tgf-β(3) null mutant mouse palate plays a role in the cell proliferation defect observed.
Authors:
A Del Río; M C Barrio; J Murillo; E Maldonado; Y López-Gordillo; E Martínez-Sanz; M L Martínez; C Martínez-Álvarez
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Publication Detail:
Type:  Journal Article     Date:  2010-09-28
Journal Detail:
Title:  Cells, tissues, organs     Volume:  193     ISSN:  1422-6421     ISO Abbreviation:  Cells Tissues Organs (Print)     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883360     Medline TA:  Cells Tissues Organs     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  135-50     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Affiliation:
Departamento de Anatomía y Embriología Humana I, Facultad de Odontología, Universidad Complutense de Madrid, Madrid, España.
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