| Analysis of Photoreceptor Degeneration in the Zebrafish Danio rerio. | |
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MedLine Citation:
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PMID: 23150365 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Disturbances in the general mRNA metabolism have been recognized as a major defect in a growing number of hereditary human diseases. One prominent example of this disease group is Retinitis pigmentosa (RP), characterized by selective loss of photoreceptor cells. RP can be caused by dominant mutations in key factors of the pre-mRNA processing spliceosome. In these cases, the complex events leading to the RP phenotype can only insufficiently be analyzed in rodents or other model organisms due to the essential functions of these splice factors. Here we introduce the zebrafish Danio rerio as a valuable vertebrate model system to study RP and related diseases. |
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Authors:
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Holger Dill; Bastian Linder; Anja Hirmer; Utz Fischer |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 935 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2013 |
Date Detail:
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Created Date: 2012-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: - |
Other Details:
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Languages: ENG Pagination: 127-137 Citation Subset: - |
Affiliation:
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Department of Biochemistry, Biocenter, University of Würzburg, Würzburg, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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