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Analysis of Photoreceptor Degeneration in the Zebrafish Danio rerio.
MedLine Citation:
PMID:  23150365     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Disturbances in the general mRNA metabolism have been recognized as a major defect in a growing number of hereditary human diseases. One prominent example of this disease group is Retinitis pigmentosa (RP), characterized by selective loss of photoreceptor cells. RP can be caused by dominant mutations in key factors of the pre-mRNA processing spliceosome. In these cases, the complex events leading to the RP phenotype can only insufficiently be analyzed in rodents or other model organisms due to the essential functions of these splice factors. Here we introduce the zebrafish Danio rerio as a valuable vertebrate model system to study RP and related diseases.
Authors:
Holger Dill; Bastian Linder; Anja Hirmer; Utz Fischer
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  935     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  127-137     Citation Subset:  -    
Affiliation:
Department of Biochemistry, Biocenter, University of Würzburg, Würzburg, Germany.
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