Document Detail


Analysis of O6-methylguanine-DNA methyltransferase methylation status in sporadic colon polyps.
MedLine Citation:
PMID:  24376999     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIM: The aim of our study was to check how MGMT methylation status together with known factors influenced the risk of colon cancer development.
MATERIALS AND METHODS: We examined patients with colon polyps. Information concerning gender, age, lifestyle, diet, anthropometry and medical information, including cancer and family history of cancer, was analyzed. Polymorphism variety of MGMT gene was investigated in another study. Genetic analysis for MGMT methylation assessment was performed for polyp tissue samples from 143 patients.
RESULTS: Positive methylation MGMT status was found in 55 patients. There was no correlation between gender and MGMT methylation status (p = 0.43). We did not find correlation between patients younger and older than 60 (p = 0.87). There was no correlation between smoking and MGMT methylation status (p = 0.36). We did not find correlation between BMI and MGMT methylation status (p = 0.86). We did not find correlation between MGMT methylation status and colon cancer in familial history (p = 0.45).
CONCLUSION: Our study showed no correlations between methylation status of MGMT polymorphisms and clinical features like age, gender, polyp localization, smoking status, or obesity. It has been shown previously that MGMT methylation status may show nonspecific methylation in colon polyps. Gene methylation status in adenoma tissues has also been associated by other authors with the adenoma's size, histology, and degree of atypia. In our study, we evaluated the gene methylation status in colon polyps and found no association with adenoma characteristics. The present study showed no correlation for MGMT methylation in polyps in different regions of colon.
Authors:
Witold Kycler; Bronisława Szarzyńska; Cezary Loziński; Konstanty Korski; Katarzyna Lamperska
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Publication Detail:
Type:  Journal Article     Date:  2012-01-23
Journal Detail:
Title:  Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology     Volume:  17     ISSN:  1507-1367     ISO Abbreviation:  Rep Pract Oncol Radiother     Publication Date:  2012  
Date Detail:
Created Date:  2013-12-30     Completed Date:  2013-12-30     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  100885761     Medline TA:  Rep Pract Oncol Radiother     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  -    
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