Document Detail


Analysis of MEG background activity in Alzheimer's disease using nonlinear methods and ANFIS.
MedLine Citation:
PMID:  19130227     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to analyze the magnetoencephalogram (MEG) background activity from 20 patients with probable Alzheimer's disease (AD) and 21 control subjects by using two nonlinear methods: sample entropy (SampEn), and Lempel-Ziv complexity (LZC). The former quantifies the signal regularity, and the latter is a complexity measure. The signals were acquired with a 148-channel whole-head magnetometer placed in a magnetically shielded room. Our results show that MEG recordings are less complex and more regular in patients with AD than in control subjects. Significant differences between both groups were found in 16 MEG channels with SampEn and in 134 with LZC (p < 0.01, Student's t test with Bonferroni's correction). Using receiver operating characteristic curves with a leave-one-out cross-validation procedure, accuracies of 70.73 and 78.05% were reached with SampEn and LZC, respectively. Additionally, we wanted to assess whether both nonlinear methods and an adaptive-network-based fuzzy interference system (ANFIS) could improve AD diagnosis. With this classifier, an accuracy of 85.37% was achieved. Our findings suggest the usefulness of our methodology to increase our insight into AD.
Authors:
Carlos Gómez; Roberto Hornero; Daniel Abásolo; Alberto Fernández; Javier Escudero
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-07
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  37     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-03     Completed Date:  2009-04-15     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  586-94     Citation Subset:  IM    
Affiliation:
Biomedical Engineering Group, Department of Signal Theory and Communications, E.T.S. Ingenieros de Telecomunicación, University of Valladolid, Campus Miguel Delibes, Camino del Cementerio s/n, 47011 Valladolid, Spain. cargom@tel.uva.es
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MeSH Terms
Descriptor/Qualifier:
Algorithms*
Alzheimer Disease / diagnosis*,  physiopathology*
Diagnosis, Computer-Assisted / methods*
Fuzzy Logic*
Humans
Magnetoencephalography / methods*
Neural Networks (Computer)*
Nonlinear Dynamics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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