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Analysis of the Lymphocytopoiesis Dynamics in Nonirradiated and Irradiated Humans: A Modeling Approach.
MedLine Citation:
PMID:  24673256     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this work, a recently developed mathematical model of the lymphocytopoietic system in acutely irradiated humans was extended to predict the dynamics of this system both in nonirradiated and acutely/chronically irradiated humans. The mathematical implementation of this model is a system of nonlinear ordinary differential equations, whose variables and parameters have clear biological meaning. We demonstrate that the model is capable of reproducing the dynamic regimes that are typical for lymphocytopoiesis in nonirradiated individuals with a hematological disorder (cyclic lymphocytopenia) and in patients receiving allogeneic stem cell transplantation. The model is also capable of predicting the dynamics of the lymphocytopoietic system in humans exposed to acute and chronic irradiation over a wide range of doses and dose rates. Additionally, the "lethal" dose rate of chronic irradiation, evaluated in the framework of the lymphocytopoiesis model, agrees with the actual minimum dose rate of lethal chronic irradiation observed for humans.
Authors:
Olga A Smirnova; Shaowen Hu; Francis A Cucinotta
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-27
Journal Detail:
Title:  Radiation research     Volume:  -     ISSN:  1938-5404     ISO Abbreviation:  Radiat. Res.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401245     Medline TA:  Radiat Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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