| Analysis of the LRRK2 Gly2385Arg variant in Alzheimer's disease in Taiwan. | |
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MedLine Citation:
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PMID: 19640773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To analyze the Gly2385Arg (G2385R) mutation in Taiwanese Alzheimer's disease (AD) patients. BACKGROUND: The leucine-rich repeat kinase 2 (LRRK2) gene is well known to predispose subjects to Parkinson's disease (PD). The Gly2385Arg (G2385R) variant of LRRK2 is believed to be "East Asian"-specific, particularly in the Han Chinese population; however, whether the LRRK2 G2385R is associated with a risk of AD in pure Han-Chinese patients has not often been studied. METHODS: A total of 209 AD patients (87 men, 122 women) and 180 age- and gender-matched controls were recruited and the demographic data of the AD patients were analyzed. Genotyping of the Gly2385Arg variant was studied using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. RESULTS: Subjects with the Gly2385Arg variant were all heterozygous carriers. The frequency of Gly2385Arg carriers did not differ significantly between the AD patients and controls (4.78% versus 4.44%, odds ratio=1.04, 95% CI=0.62-1.77, P=0.87). In the AD patient group, the age of symptom onset, the length of education, or the MMSE score showed no significant differences between wild-type carriers and heterozygous variant carriers (P=0.51, 0.43, and 0.09). CONCLUSION: The Gly2385Arg variant of LRRK2 may not be a major risk factor for AD in pure Han Chinese patient. Among the AD patients, Gly2385Arg carriers were not clinically different from wild-type carriers. |
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Authors:
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Ting-Yu Chang; Hung-Chou Kuo; Chin-Song Lu; Yah-Huei Wu-Chou; Chin-Chang Huang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-28 |
Journal Detail:
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Title: Parkinsonism & related disorders Volume: 16 ISSN: 1873-5126 ISO Abbreviation: Parkinsonism Relat. Disord. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-23 Revised Date: 2012-06-25 |
Medline Journal Info:
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Nlm Unique ID: 9513583 Medline TA: Parkinsonism Relat Disord Country: England |
Other Details:
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Languages: eng Pagination: 28-30 Citation Subset: IM |
Affiliation:
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Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / genetics* Arginine / genetics* DNA Mutational Analysis / methods Female Gene Frequency Genetic Predisposition to Disease* Genotype Glycine / genetics* Humans Male Middle Aged Polymorphism, Single Nucleotide* Protein-Serine-Threonine Kinases / genetics* Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods Taiwan / ethnology |
| Chemical | |
Reg. No./Substance:
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56-40-6/Glycine; 74-79-3/Arginine; EC 2.7.11.1/LRRK2 protein, human; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
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