Document Detail


Analysis of the LRRK2 Gly2385Arg variant in Alzheimer's disease in Taiwan.
MedLine Citation:
PMID:  19640773     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To analyze the Gly2385Arg (G2385R) mutation in Taiwanese Alzheimer's disease (AD) patients.
BACKGROUND: The leucine-rich repeat kinase 2 (LRRK2) gene is well known to predispose subjects to Parkinson's disease (PD). The Gly2385Arg (G2385R) variant of LRRK2 is believed to be "East Asian"-specific, particularly in the Han Chinese population; however, whether the LRRK2 G2385R is associated with a risk of AD in pure Han-Chinese patients has not often been studied.
METHODS: A total of 209 AD patients (87 men, 122 women) and 180 age- and gender-matched controls were recruited and the demographic data of the AD patients were analyzed. Genotyping of the Gly2385Arg variant was studied using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry.
RESULTS: Subjects with the Gly2385Arg variant were all heterozygous carriers. The frequency of Gly2385Arg carriers did not differ significantly between the AD patients and controls (4.78% versus 4.44%, odds ratio=1.04, 95% CI=0.62-1.77, P=0.87). In the AD patient group, the age of symptom onset, the length of education, or the MMSE score showed no significant differences between wild-type carriers and heterozygous variant carriers (P=0.51, 0.43, and 0.09).
CONCLUSION: The Gly2385Arg variant of LRRK2 may not be a major risk factor for AD in pure Han Chinese patient. Among the AD patients, Gly2385Arg carriers were not clinically different from wild-type carriers.
Authors:
Ting-Yu Chang; Hung-Chou Kuo; Chin-Song Lu; Yah-Huei Wu-Chou; Chin-Chang Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-28
Journal Detail:
Title:  Parkinsonism & related disorders     Volume:  16     ISSN:  1873-5126     ISO Abbreviation:  Parkinsonism Relat. Disord.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-23     Revised Date:  2012-06-25    
Medline Journal Info:
Nlm Unique ID:  9513583     Medline TA:  Parkinsonism Relat Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  28-30     Citation Subset:  IM    
Affiliation:
Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / genetics*
Arginine / genetics*
DNA Mutational Analysis / methods
Female
Gene Frequency
Genetic Predisposition to Disease*
Genotype
Glycine / genetics*
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide*
Protein-Serine-Threonine Kinases / genetics*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
Taiwan / ethnology
Chemical
Reg. No./Substance:
56-40-6/Glycine; 74-79-3/Arginine; EC 2.7.11.1/LRRK2 protein, human; EC 2.7.11.1/Protein-Serine-Threonine Kinases

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