Document Detail


Analysis of KIR gene frequencies and HLA class I genotypes in breast cancer and control group.
MedLine Citation:
PMID:  23792055     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Breast cancer is the main cause of cancer-related death among women, with a 0.5% increase in incidence per year. Natural killer cells (NK) are part of the innate immune system recognizing class I HLA molecules on target cells through their membrane receptors, called killer cell immunoglobulin-like receptors (KIR). The aim of our study was to evaluate the association between the KIR genes and HLA alleles in patients with breast cancer and healthy controls. Two hundred thirty patients with breast cancer and 272 healthy controls were typed for HLA class I and KIR genes by PCR-SSO. When both groups were compared, the presence of inhibitory KIR2DL2 receptors was significantly higher in breast cancer patients than in healthy controls. No significant differences were found for HLA-C2 and HLA-Bw4. However, a higher frequency of HLA-C1 in breast cancer patients was observed. These findings suggest a potential role for the KIR gene system in breast cancer. Further studies to confirm this observation are warranted.
Authors:
Maria Regina Jobim; Mariana Jobim; Patrícia H Salim; Pâmela Portela; Luiz Fernando Jobim; Sandra Leistner-Segal; Ana Cristina Bittelbrunn; Carlos Henrique Menke; Jorge Villanova Biazús; Rafael Roesler; Gilberto Schwartsmann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-17
Journal Detail:
Title:  Human immunology     Volume:  -     ISSN:  1879-1166     ISO Abbreviation:  Hum. Immunol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier Inc.
Affiliation:
Department of Immunology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
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