Document Detail

Analysis of HLA-DRB1 alleles in Japanese patients with chronic myelogenous leukemia.
MedLine Citation:
PMID:  10629577     Owner:  NLM     Status:  MEDLINE    
To clarify the association between HLA-DRB1 alleles and chronic myelogenous leukemia (CML), the HLA-DRB1 allele frequencies in 50 Japanese patients each with b2a2 and b3a2 CML and 127 healthy Japanese individuals were examined. In the patients with b2a2 CML, the frequencies of HLA-DRB1*0405, DRB1*08032, and DRB1*1502 were low and that of HLA-DRB1*1201 was high in comparison with the healthy individuals. The frequencies of HLA-DRB1*0403, DRB1*0802, DRB1*1403, and DRB1*1405 were high, and those of HLA-DRB1*08032 and DRB1*1501 were low in the patients with b3a2 CML. The present results suggest positive and negative associations between certain HLA-DRB1 alleles and CML.
M Yasukawa; H Ohminami; K Kojima; K Inokuchi; Y Nishimura; S Fujita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hematology     Volume:  63     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-02-16     Completed Date:  2000-02-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  99-101     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Wiley-Liss, Inc.
First Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.
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MeSH Terms
Fusion Proteins, bcr-abl / genetics
Gene Frequency / genetics*
HLA-DR Antigens / genetics*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*,  metabolism
Polymorphism, Restriction Fragment Length
Reference Values
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/Fusion Proteins, bcr-abl; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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