Document Detail


Analysis of HIV type 1 diversity in pregnant women from four Latin American and Caribbean countries.
MedLine Citation:
PMID:  17147509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Worldwide, the distribution of HIV-1 subtypes and intersubtype recombinants is not homogeneous. In Latin America and the Caribbean, HIV-1 subtype B predominates. However, in the south of Brazil and in countries of the Southern cone (Argentina, Chile, Paraguay, and Uruguay) there is a different distribution of viral subtypes and intersubtype recombinants. The aim of this work was to analyze HIV-1 diversity in a cohort of pregnant women (with primarily heterosexual acquisition of the infection) who were diagnosed with HIV-1 infection during their current pregnancy and who received ARVs during pregnancy for perinatal transmission prophylaxis. Analysis of 121 partial pol sequences from subjects enrolled in Argentina, Brazil, the Bahamas, and Mexico was performed by phylogenetic and recombinant characterization. Different prevalences of subtype B were observed (100% for specimens from Mexico and the Bahamas, 61% for Brazil, and 30% for Argentina). Subtypes C and F were found, along with BC, BF, FC, and CBF recombinants in specimens from Brazilians. A high prevalence of BF recombinants was found (70%) in specimens from Argentina. The different patterns of HIV- 1 subtypes and intersubtype recombinants in South America (Argentina and Brazil) compared to those in Central and North America should be considered in the design of future HIV-1 vaccine trials.
Authors:
Manuel Gomez-Carrillo; Sandra Pampuro; Adriana Duran; Marcelo Losso; D Robert Harris; Jennifer S Read; Geraldo Duarte; Ricardo De Souza; Luis Soto-Ramirez; Horacio Salomón;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  22     ISSN:  0889-2229     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-12-06     Completed Date:  2007-01-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1186-91     Citation Subset:  IM; X    
Affiliation:
Centro Nacional de Referencia para el SIDA, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Argentina / epidemiology
Bahamas / epidemiology
Brazil / epidemiology
Female
Gene Products, pol / genetics
Genetic Variation*
HIV Infections / epidemiology*,  virology*
HIV-1 / genetics*,  isolation & purification*
Humans
Mexico / epidemiology
Phylogeny
Pregnancy
Grant Support
ID/Acronym/Agency:
N01-HD-3-3345/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Gene Products, pol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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