Document Detail


Analysis of the E-cadherin repressor Snail in primary human cancers.
MedLine Citation:
PMID:  17587826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epithelial-mesenchymal transition (EMT), a normal developmental process, is known to play a crucial role in tumor progression. Molecules involved in this process, such as the E-cadherin repressor Snail, facilitate migration and invasion of carcinoma cells. A growing number of studies addressing the expression of Snail in clinical samples have been reported and are discussed in this review. A total of 2,112 cases from 9 different tumor types were evaluated. So far, a clear picture has emerged only in some cancer types analyzed with regard to overexpression of Snail and clinical-pathological parameters. Currently, it seems that Snail may play a role in hormone-dependent carcinomas but may be of minor importance in gastrointestinal cancers for tumor dedifferentiation and the maintenance of the invasive phenotype. It should be kept in mind, however, that the threshold for Snail activity does not have to be the same in every tumor type analyzed. The recent introduction of well-characterized novel monoclonal antibodies reacting with the short-lived nuclear Snail protein may help to establish a potential clinical usefulness for this master molecule of EMT, at least for certain types of cancer.
Authors:
K-F Becker; E Rosivatz; K Blechschmidt; E Kremmer; M Sarbia; H Höfler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cells, tissues, organs     Volume:  185     ISSN:  1422-6421     ISO Abbreviation:  Cells Tissues Organs (Print)     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883360     Medline TA:  Cells Tissues Organs     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  204-12     Citation Subset:  IM    
Copyright Information:
2007 S. Karger AG, Basel
Affiliation:
Institut für Pathologie, Technische Universität München, Munich, Germany. kf.becker@lrz.tum.de
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MeSH Terms
Descriptor/Qualifier:
Cadherins / genetics,  metabolism
Epithelial Cells / pathology
Humans
Mesoderm / pathology
Neoplasms / classification,  genetics,  metabolism,  pathology*
Repressor Proteins / genetics,  metabolism*
Transcription Factors / analysis*
Chemical
Reg. No./Substance:
0/Cadherins; 0/Repressor Proteins; 0/Transcription Factors; 0/snail family transcription factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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