Document Detail


Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma.
MedLine Citation:
PMID:  22250480     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
THE AIMS OF OUR STUDY WERE: (i) to find a design and validate a method for fast and reliable analysis of the D1853N (5557G>A) genetic polymorphism in the ATM (ataxia-telangiectasia mutated) gene; (ii) to use side-directed mutagenesis to generate ATM 5557A-positive DNA (reference ATM5557A DNA); and (iii) to analyze a group of patients suffering from cervical carcinoma with adverse responses to radiotherapy. The 5557A variant was found in three of twenty women (15%). Our data show that the prevalence of the 5557A allelic variant in cervical cancer subjects with adverse responses after irradiation probably does not differ from the prevalence common in Caucasians. A larger population study should confirm these preliminary results.
Authors:
Martin Beránek; Monika Drastíková; Simona Paulíková; Igor Sirák; Milan Vosmik; Jirí Petera
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové     Volume:  54     ISSN:  1211-4286     ISO Abbreviation:  Acta Medica (Hradec Kralove)     Publication Date:  2011  
Date Detail:
Created Date:  2012-01-18     Completed Date:  2012-02-07     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9705947     Medline TA:  Acta Medica (Hradec Kralove)     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  111-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Ataxia Telangiectasia Mutated Proteins
Carcinoma, Squamous Cell / genetics*,  radiotherapy
Cell Cycle Proteins / genetics*
DNA-Binding Proteins / genetics*
Female
Humans
Middle Aged
Mutagenesis, Site-Directed
Polymerase Chain Reaction
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length
Protein-Serine-Threonine Kinases / genetics*
Radiation Tolerance / genetics*
Sequence Analysis, DNA
Sequence Homology, Nucleic Acid
Tumor Suppressor Proteins / genetics*
Uterine Cervical Neoplasms / genetics*,  radiotherapy
Chemical
Reg. No./Substance:
0/Cell Cycle Proteins; 0/DNA-Binding Proteins; 0/Tumor Suppressor Proteins; EC 2.7.11.1/ATM protein, human; EC 2.7.11.1/Ataxia Telangiectasia Mutated Proteins; EC 2.7.11.1/Protein-Serine-Threonine Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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