| Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma. | |
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MedLine Citation:
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PMID: 22250480 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Clinical oncologists have been focusing their efforts on attempting to define risk groups of patients with unusual biological reactions to the recommended therapy regimens using molecular biology techniques. The aims of our study were: (i) to find a design and validate a method for fast and reliable analysis of the D1853N (5557G>A) genetic polymorphism in the ATM (ataxia-telangiectasia mutated) gene; (ii) to use side-directed mutagenesis to generate ATM 5557A-positive DNA (reference ATM5557A DNA); and (iii) to analyze a group of patients suffering from cervical carcinoma with adverse responses to radiotherapy. The 5557A variant was found in three of twenty women (15%). Our data show that the prevalence of the 5557A allelic variant in cervical cancer subjects with adverse responses after irradiation probably does not differ from the prevalence common in Caucasians. A larger population study should confirm these preliminary results. |
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Authors:
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Martin Beránek; Monika Drastíková; Simona Paulíková; Igor Sirák; Milan Vosmik; Jirí Petera |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové Volume: 54 ISSN: 1211-4286 ISO Abbreviation: Acta Medica (Hradec Kralove) Publication Date: 2011 |
Date Detail:
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Created Date: 2012-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705947 Medline TA: Acta Medica (Hradec Kralove) Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 111-6 Citation Subset: IM |
Affiliation:
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Institute of Clinical Biochemistry and Diagnostics, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Czech Republic. beranek@lfhk.cuni.cz |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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