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Analysis of the Cutoff Values in Fibrin-Related Markers for the Diagnosis of Overt DIC.
MedLine Citation:
PMID:  22203032     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Fibrin-related markers (FRMs) such as fibrin and fibrinogen degradation products (FDPs), <scp>d</scp>-dimer, and soluble fibrin monomer complex (SFMC) were prospectively evaluated in 522 patients using the overt disseminated intravascular coagulation (DIC) diagnostic criteria. The differences in all FRMs between the DIC group and the non-DIC group, and those between the survivors and nonsurvivors were significant in the patients with infections. In an analysis of all patients, DIC score cutoff values of 2 and 3 points for FDP, <scp>d</scp>-dimer, and SFMC were recommended to be 8.3 and 42.0 μg/mL, 2.4 and 22.0 μg/mL, and 3.4 and 138.0 μg/mL, respectively. In conclusion, the adequate cutoff value is thus considered to be useful for both making a diagnosis of DIC and for predicting the outcome. Fibrin-related markers are therefore thought to be more useful for making a diagnosis of DIC based on infections than based on any other underlying disorders.
Authors:
Tsuyoshi Hatada; Hideo Wada; Kazuo Kawasugi; Kohji Okamoto; Toshimasa Uchiyama; Shigeki Kushimoto; Yoshinobu Seki; Takashi Okamura; Hiroshi Imai; Toshihiro Kaneko; Tsutomu Nobori
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-26
Journal Detail:
Title:  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis     Volume:  -     ISSN:  1938-2723     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508125     Medline TA:  Clin Appl Thromb Hemost     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Emergency Critical Care Center, Mie University Hospital, Tsu, Japan.
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