Document Detail

Analysis of CAG repeat expansions in restless legs syndrome.
MedLine Citation:
PMID:  14746390     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: A relatively high prevalence of restless legs syndrome symptoms has been recently reported in a substantial proportion of patients affected with spinocerebellar ataxia type 3. Our aim was to investigate whether there is a common genetic etiology between restless legs syndrome and spinocerebellar ataxia type 3. DESIGN: Systematic differences in the number of spinocerebellar ataxia type 3 trinucleotide repeat were investigated by means of an association study. The relationship between the size of the expanded alleles and several clinical features was also considered. PARTICIPANTS AND SETTING: 125 extensively characterized restless legs syndrome patients compared with 188 healthy controls matched for ethnic background. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: No CAG repeat expansions in the pathologic or intermediate range were detected in any of the examined subjects, including patients and controls. A similar allelic distribution was observed in both groups (Mann-Whitney U test = 78406; P = 0.99). Moreover, stratification analyses of the patients' samples according to different clinical and polysomnographic variables disclosed no significant differences. CONCLUSIONS: These results do not provide evidence toward an involvement of large CAG trinucleotide expansions at the spinocerebellar ataxia type 3 locus in idiopathic restless legs syndrome.
Alex Desautels; Gustavo Turecki; Jacques Montplaisir; Katéri Brisebois; Amélie K Desautels; Benoît Adam; Guy A Rouleau
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Sleep     Volume:  26     ISSN:  0161-8105     ISO Abbreviation:  Sleep     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-28     Completed Date:  2004-03-25     Revised Date:  2009-01-29    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1055-7     Citation Subset:  IM    
Centre d'étude du sommeil, Hôpital du Sacré-Caeur de Montréal, Centre de recherche en sciences neurologiques, Université de Montréal, Québec, Canada.
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MeSH Terms
Gene Frequency / genetics
Middle Aged
Polysomnography / methods
Restless Legs Syndrome / diagnosis,  genetics*
Spinocerebellar Ataxias / genetics
Trinucleotide Repeats / genetics*
Wakefulness / physiology
Grant Support

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