Document Detail


Analysis of the C609T polymorphism of NQO1 gene in South Croatian patients with hematological malignancies.
MedLine Citation:
PMID:  21755707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study we analyzed the effect of polymorphic variation of NAD(P)H: quinone oxidoreductase1 (NQO1) gene that encode enzyme which detoxifies harmful quinines and protect hematopoietic stem cells against oxidative stress. C609T polymorphism of NQO1 gene leads to loss of enzyme activity, which may be a risk factor in the etiology of specific types of hematopoietic malignancies. We analyzed C609T polymorphism in NQO1 gene in the group of 82 patients (56 adult and 26 children) with different type of hematopoietic malignancies and 99 healthy participants (61 adult and 38 children) using PCR and the RFLP method. We confirmed that the polymorphism C609T in NQO1 gene was more frequent in the adult patients' group with myeloid disorders, (p = 0.0267) compared with adult controls. We could not confirm the association C609T polymorphism with recurrent chromosome translocations (clonal karyotype changes) neither in the adult nor in pediatric group of patients.
Authors:
Bernarda Lozić; Dragan Primorac; Robert Glavinić; Radenka Kuzmanić Samija; Tatijana Zemunik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Collegium antropologicum     Volume:  35     ISSN:  0350-6134     ISO Abbreviation:  Coll Antropol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-07-15     Completed Date:  2011-08-25     Revised Date:  2012-05-28    
Medline Journal Info:
Nlm Unique ID:  8003354     Medline TA:  Coll Antropol     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  385-8     Citation Subset:  IM    
Affiliation:
University of Split, Split University Hospital Center, Department of Pediatrics, Split, Croatia.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Child
Child, Preschool
Female
Gene Frequency
Genetic Predisposition to Disease
Hematologic Neoplasms / genetics*
Humans
Infant
Male
Middle Aged
NAD(P)H Dehydrogenase (Quinone) / genetics*
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Chemical
Reg. No./Substance:
EC 1.6.5.2/NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2/NQO1 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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