Document Detail

Analysis of 6381 hepatocellular carcinoma patients in southern Taiwan: prognostic features, treatment outcome, and survival.
MedLine Citation:
PMID:  18306990     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This hospital-based analysis was conducted to identify prognostic factors of hepatocellular carcinoma (HCC) in a hepatitis B virus endemic area. METHODS: A total of 6381 HCC cases, diagnosed from 1986 to 2002, were enrolled, and 2890 (42.3%) of them were not treated. Survival rates were analyzed by correlation with the national mortality databank. Missing data and correlations among prognostic factors were considered in the analysis. RESULTS: The overall 1-year, 3-year, 5-year, and 7-year survival rates were 44.3%, 24.9%, 17.1%, and 13%, respectively. Multivariate analysis revealed that the independent factors influencing survival were the initial treatment modality, degree of liver function impairment, hepatitis B surface antigen positivity, tumor status, and alpha-fetoprotein. Besides these well-known prognostic factors, high alanine aminotransferase (ALT) levels and a high aspartate aminotransferase (AST)/ALT ratio were identified as independent poor prognostic factors. CONCLUSIONS: This study, which considered untreated cases, missing data, and correlations between variables and official survival data sets, provides a large-scale comprehensive survival analysis. According to our results, high ALT and high AST/ALT were independent poor prognostic factors. Therefore, viral activity should be controlled in HCC patients, and patients with elevated AST/ALT ratios should be carefully monitored.
Chi-Sin Changchien; Chao-Long Chen; Yi-Hao Yen; Jing-Houng Wang; Tsung-Hui Hu; Chuan-Mo Lee; Chih-Chi Wang; Yu-Fan Cheng; Yu-Jie Huang; Chih-Yun Lin; Sheng-Nan Lu
Publication Detail:
Type:  Journal Article     Date:  2008-02-29
Journal Detail:
Title:  Journal of gastroenterology     Volume:  43     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-29     Completed Date:  2008-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  159-70     Citation Subset:  IM    
Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University of Medicine, 123 Tapei Rd., Niaosung, 833, Kaohsiung, Taiwan.
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MeSH Terms
Carcinoma, Hepatocellular / epidemiology*,  mortality
Hepatic Veins / pathology
Liver Neoplasms / epidemiology*,  mortality
Lymphatic Metastasis
Middle Aged
Multivariate Analysis
Neoplasm Invasiveness
Portal Vein / pathology
Survival Analysis
Taiwan / epidemiology
Treatment Outcome

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