Document Detail

Analysis of 31 families with an apparently autosomal-dominant transmission of migraine with aura in the nuclear family.
MedLine Citation:
PMID:  9259375     Owner:  NLM     Status:  MEDLINE    
We analyzed 31 families selected for an apparently autosomal-dominant mode of inheritance of migraine with aura (MA) in the nuclear family. The nuclear families were expanded with first- and second-degree relatives. All interviews were made by physicians experienced in headache diagnoses. The criteria of the International Headache Society were used. The population relative risk among children in nuclear families was similar to the estimated population relative risk of MA assuming an autosomal-dominant mode of inheritance. The population relative risk tended to decrease among first-degree relatives outside nuclear families and further among second-degree relatives. Both first- and second-degree relatives outside the nuclear families had a statistically significant lower risk of MA than expected. Thus, autosomal-dominant inheritance with or without reduced penetrance was unlikely. Autosomal-recessive inheritance was unlikely because of the unequal sex distribution. Other modes of inheritance were considered as well. Mitochondrial and X-linked inheritance were excluded because of paternal transmission. The female preponderance was too low to explain sex-influenced inheritance. We conclude that MA most likely has a multifactorial inheritance even in high-risk families with MA.
V Ulrich; M B Russell; S Ostergaard; J Olesen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of medical genetics     Volume:  74     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-11-06     Completed Date:  1997-11-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  395-7     Citation Subset:  IM    
Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.
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MeSH Terms
Child, Preschool
Denmark / epidemiology
Genes, Dominant*
Middle Aged
Migraine Disorders / epidemiology,  genetics*
Sex Factors

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