| Analysis of 2000 consecutive UK tonsillectomy specimens for disease-related prion protein. | |
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MedLine Citation:
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PMID: 15464187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Variant Creutzfeldt-Jakob disease (CJD) is thought to be caused by dietary or other exposure to bovine spongiform encephalopathy (BSE) prions. The prevalence of preclinical or subclinical prion infection in the UK is currently unknown. Since clinical variant CJD is uniformly associated with tonsillar prion infection, we screened 2000 anonymous surgical tonsillectomy specimens for disease-associated prion protein. Analysis by both high sensitivity immunoblotting and immunohistochemistry detected no positive cases. However, this negative result cannot provide reassurance that relevant community infection is unlikely because of the fairly small sample size, demographic and age-related factors, and unknown test sensitivity during the prolonged incubation period. Nevertheless, our findings establish a protocol for prevalence screening on a national scale. |
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Authors:
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Adam Frosh; Lorraine C Smith; Carl J Jackson; Jacqueline M Linehan; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lancet Volume: 364 ISSN: 1474-547X ISO Abbreviation: Lancet Publication Date: 2004 Oct 2-8 |
Date Detail:
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Created Date: 2004-10-06 Completed Date: 2004-10-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: England |
Other Details:
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Languages: eng Pagination: 1260-2 Citation Subset: AIM; IM |
Affiliation:
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MRC Prion Unit and Department of Neurodegenerative Disease, Institute of Neurology, University College, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Chemistry Child Creutzfeldt-Jakob Syndrome / diagnosis, epidemiology Cricetinae Great Britain / epidemiology Humans Immunoblotting Immunohistochemistry Palatine Tonsil / chemistry* PrPSc Proteins / analysis Prevalence Prion Diseases / diagnosis, epidemiology Prions / isolation & purification* Tonsillectomy |
| Chemical | |
Reg. No./Substance:
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0/PrPSc Proteins; 0/Prions |
| Comments/Corrections | |
Comment In:
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Lancet. 2004 Oct 2-8;364(9441):1196-7
[PMID:
15464165
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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