Document Detail


Analyses of reported family history of glaucoma: a preliminary investigation. The Barbados Eye Study Group.
MedLine Citation:
PMID:  8956317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated the self-reported family history of open-angle glaucoma (OAG) among 4,314 black participants in the Barbados Eye Study (BES), which was based on a random sample of Barbados-born citizens between 40 and 84 years of age. Data collection included Humphrey perimetry, fundus photography, various ophthalmic and other measurements and a comprehensive interview, including family history. Results showed that participants with OAG and previous OAG treatment reported more family history; maternal history was reported twice as often as paternal history. In persons without previous OAG treatment, those with newly diagnosed OAG reported more sibling history (Odds Ratio = 4.5). The Statistical Analysis for Genetic Epidemiology (S.A.G.E.) system was used to test the transmission models for OAG in a subset of 1,048 families (5,806 individuals) with the most complete self-reported family information. The S.A.G.E. results are consistent with the existence of a major dominant allele for OAG. These results should be viewed as promising, but preliminary, since they are based on self-reported data. More definitive information is currently being collected by the Barbados Family Study of Open-angle Glaucoma.
Authors:
B Nemesure; M C Leske; Q He; N Mendell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Ophthalmic epidemiology     Volume:  3     ISSN:  0928-6586     ISO Abbreviation:  Ophthalmic Epidemiol     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-02-18     Completed Date:  1997-02-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9435674     Medline TA:  Ophthalmic Epidemiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  135-41     Citation Subset:  IM    
Affiliation:
University Medical Center at Stony Brook, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group
Aged
Bias (Epidemiology)
Family Health
Female
Glaucoma, Open-Angle / epidemiology*,  genetics*
Humans
Hypertension / epidemiology
Male
Middle Aged
Prevalence
Risk Factors
Self Disclosure
Grant Support
ID/Acronym/Agency:
EY07617/EY/NEI NIH HHS; EY07625/EY/NEI NIH HHS; I P41 RR03655/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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