Document Detail

Analyses of the potential oxygen transfer capability in placentae from infants succumbing to sudden infant death syndrome.
MedLine Citation:
PMID:  14757264     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Morphometric oxygen diffusive conductance (Dp) was estimated to assess the potential efficiency of oxygen transfer across the materno-fetal interface in placentae obtained from victims of sudden infant death syndrome (SIDS). STUDY DESIGN: SIDS placentae were retrieved from archived storage and classified into normal birth weight (NBW, n=16), or small for gestational age (SGA, n=9) and compared against control placentae (n=40) or SGA (n=24) placentae. A combination of stereological techniques and physiological constants were used to estimate total Dp. RESULTS: SIDS NBW cases showed a crucial reduction in fetal capillary surface area when compared with control placentae. SIDS SGA showed a number of deficiencies in basic volumetric and surface area parameters. Values for total and specific Dp in placentae in both SIDS groups were maintained at levels comparable with control and SGA cases, respectively. CONCLUSION: Since more reductions were observed in SIDS SGA group, this suggests that factors responsible for these reductions maybe associated with SGA rather than being SIDS-specific factors.
T Ansari; J E Gillan; D Condell; C J Green; P D Sibbons
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Early human development     Volume:  76     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-03     Completed Date:  2004-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  127-38     Citation Subset:  IM    
Department of Surgical Research, Northwick Park Institute of Medical Research, Northwick Park Hospital Harrow, Middlesex, HA1 3UJ, UK.
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MeSH Terms
Gestational Age
Infant, Newborn
Infant, Small for Gestational Age
Maternal-Fetal Exchange / physiology*
Oxygen / metabolism*
Oxygen Consumption*
Placenta / blood supply,  metabolism*,  pathology
Sudden Infant Death* / etiology,  pathology
Reg. No./Substance:

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