Document Detail


Analogues of erectile dysfunction drugs: an under-recognised threat.
MedLine Citation:
PMID:  17914141     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate the problem of drug analogue adulteration in male erectile dysfunction health products. DESIGN: Survey of over-the-counter male erectile dysfunction health products available in convenience stores and pharmacies in Hong Kong. SETTING: Tertiary referral centre for clinical toxicology analysis in Hong Kong. MAIN OUTCOME MEASURES: The pattern and extent of adulteration of male erectile dysfunction health products with sildenafil, tadalafil, and vardenafil as well as their structurally modified analogues. RESULTS: Of 26 products studied, one (4%) was found to contain undeclared sildenafil, while 14 (54%) contained drug analogues of different kinds. The latter included acetildenafil, hydroxyacetildenafil, hydroxyhomosildenafil, and piperidenafil. The first three were analogues of sildenafil and the last was an analogue of vardenafil. One young patient presented with ataxia after taking an acetildenafil-containing product. CONCLUSIONS: The positive rate of concealed drug analogues in male erectile dysfunction health products is alarmingly high. Such analogues are difficult to detect by ordinary laboratory methods, and might be used in an attempt to evade regulatory inspection. Without going through the stringent drug testing process, the adverse effects of these chemicals remain largely unknown and unpredictable. Effective surveillance system and control measures are needed urgently. The medical profession and the public should be alerted to this under-recognised threat.
Authors:
W T Poon; Y H Lam; C K Lai; Albert Y W Chan; Tony W L Mak
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine     Volume:  13     ISSN:  1024-2708     ISO Abbreviation:  Hong Kong Med J     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-04     Completed Date:  2008-01-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9512509     Medline TA:  Hong Kong Med J     Country:  China    
Other Details:
Languages:  eng     Pagination:  359-63     Citation Subset:  IM    
Affiliation:
Hospital Authority Toxicology Reference Laboratory, Princess Margaret Hospital, Laichikok, Hong Kong.
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MeSH Terms
Descriptor/Qualifier:
Adult
Ataxia / chemically induced*
Carbolines / chemistry
Data Collection
Drug Contamination*
Erectile Dysfunction / drug therapy
Hong Kong
Humans
Imidazoles / chemistry
Male
Nonprescription Drugs / adverse effects,  chemistry*
Phosphodiesterase Inhibitors / chemistry*,  standards
Piperazines / chemistry
Plant Preparations / adverse effects,  chemistry*
Purines / chemistry
Pyrimidinones / chemistry
Sulfones / chemistry
Triazines / chemistry
Chemical
Reg. No./Substance:
0/Carbolines; 0/Imidazoles; 0/Nonprescription Drugs; 0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Plant Preparations; 0/Purines; 0/Pyrimidinones; 0/Sulfones; 0/Triazines; 0/hydroxyacetildenafil; 0/piperidenafil; 0/tadalafil; 139755-83-2/sildenafil; 224785-90-4/vardenafil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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