| Analogues of both Leu- and Met-enkephalin containing a constrained dipeptide isostere prepared from a Baylis-Hillman adduct. | |
| | |
MedLine Citation:
|
PMID: 19585218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
An efficient route was developed for the synthesis of the Fmoc-protected dipeptide 4, isostere of Gly-Gly containing an alpha-methylene beta-amino acid; the conformationally restricted analogues of Leu-enkephalin, 3a, and Met-enkephalin, 3b, respectively, were prepared by changing 4 for Gly(2)-Gly(3) in the native compounds 3a and 3b whose biological activities were significantly lower than the parent compounds. |
| | |
Authors:
|
Roberta Galeazzi; Gianluca Martelli; Eleonora Marcucci; Mario Orena; Samuele Rinaldi; Roberta Lattanzi; Lucia Negri |
Related Documents
:
|
14527558 - Synthesis and antiparasitic activity of albendazole and mebendazole analogues. 10937728 - One-pot synthesis and biological evaluation of aspergillamides and analogues. 20449488 - Novel nucleobase-simplified cyclic adp-ribose analogue: a concise synthesis and ca(2+)-... 12825928 - Simplified discodermolide analogues: synthesis and biological evaluation of 4-epi-7-deh... 12739948 - Solution- and solid-phase parallel synthesis of 4-alkoxy-substituted pyrimidines with h... 7838878 - Synthesis and pharmacological properties of benzothiazole, 1,3-4-oxadiazole and 1,3,4-t... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-08 |
Journal Detail:
|
Title: Amino acids Volume: 38 ISSN: 1438-2199 ISO Abbreviation: Amino Acids Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-07 Completed Date: 2010-07-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9200312 Medline TA: Amino Acids Country: Austria |
Other Details:
|
Languages: eng Pagination: 1057-65 Citation Subset: IM |
Affiliation:
|
Dipartimento I.S.A.C., Università Politecnica delle Marche, Via Brecce Bianche, 60131, Ancona, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acid Sequence Animals Dipeptides / chemical synthesis*, chemistry* Drug Design Electric Stimulation Enkephalin, Leucine / analogs & derivatives*, chemistry, pharmacology* Enkephalin, Methionine / analogs & derivatives*, chemistry, pharmacology* Glycylglycine / analogs & derivatives, chemical synthesis, chemistry Guinea Pigs Ileum Male Mice Models, Molecular Molecular Conformation Molecular Mimicry Molecular Structure Myenteric Plexus / drug effects, physiology Neurotransmitter Agents / chemical synthesis*, chemistry, pharmacology* Receptors, Opioid, delta / agonists Receptors, Opioid, mu / agonists Stereoisomerism Vas Deferens |
| Chemical | |
Reg. No./Substance:
|
0/Dipeptides; 0/Neurotransmitter Agents; 0/Receptors, Opioid, delta; 0/Receptors, Opioid, mu; 556-50-3/Glycylglycine; 58569-55-4/Enkephalin, Methionine; 58822-25-6/Enkephalin, Leucine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Physiological and biochemical responses of green microalgae from different habitats to osmotic and m...
Next Document: Procalcitonin in patients with acute coronary syndromes and cardiogenic shock submitted to percutane...