Document Detail


Analogues of alpha-aminoisobutyric acid with various alkyl groups as potential tumour imaging agents; effects of chain length on tumour and normal tissue specificity.
MedLine Citation:
PMID:  2616099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eight 14C-labelled analogues of alpha-aminoisobutyric acid (AIB) were synthesized using the modified Bucherer technique to investigate their tissue distribution in Ehrlich tumour bearing mice. A structure-activity relationship within a series of AIB analogues was found; increasing the chain length of R and R' produced a progressive decrease in tumour and a dramatic decrease in normal tissue uptake. AIB and alpha-amino-2-methyl-butanoic acid (AMB) were found to have higher tumour uptake than the other six analogues; and AMB and alpha-amino-2-ethyl-butanoic acid (AEB) showed higher tumour to tissue uptake ratios than the other six analogues, significantly so for liver, stomach, heart, and small intestine. These results indicate that AMB may be a potential tumour seeking agent for emission computed tomography.
Authors:
K Shiba; H Mori; K Hisada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  10     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-03-13     Completed Date:  1990-03-13     Revised Date:  2012-01-25    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  751-8     Citation Subset:  IM    
Affiliation:
Radioisotope Centre, School of Medicine, Kanazawa University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aminobutyric Acids / diagnostic use,  pharmacokinetics*
Aminoisobutyric Acids / chemical synthesis,  diagnostic use,  pharmacokinetics
Animals
Carbon Radioisotopes / diagnostic use
Carcinoma, Ehrlich Tumor / metabolism
Mice
Neoplasms / radionuclide imaging*
Structure-Activity Relationship
Tissue Distribution
Valine / chemical synthesis,  diagnostic use,  pharmacokinetics
Chemical
Reg. No./Substance:
0/Aminobutyric Acids; 0/Aminoisobutyric Acids; 0/Carbon Radioisotopes; 2566-29-2/alpha-amino-2-ethylbutanoic acid; 595-40-4/isovaline; 7004-03-7/Valine; 80-60-4/alpha-aminobutyric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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