Document Detail

Analog simulation of aortic and of mitral regurgitation.
MedLine Citation:
PMID:  19386297     Owner:  NLM     Status:  MEDLINE    
By using an equivalent electronic circuit either mitral or aortic regurgitation was simulated. Simulation allowed not only a measurement of various pressures within the cardiovascular system and cardiac output, but also mitral and aortic flow. In normal conditions mitral and aortic flows were monophasic, anterograde. In valve regurgitation mitral and aortic flows were, as expected, biphasic. In mitral regurgitation, during systole and diastole the valve flow was retrograde and anterograde, respectively. In aortic regurgitation, during systole and diastole the valve flow was anterograde and retrograde, respectively. The magnitude of the regurgitant valve flow was measured by time-integration and compared to the net flow, i.e. cardiac output. Valve flow was determined not only by the magnitude of valve dysfunction, but also by the resistive/capacitive characteristics of the "falsely" attached regurgitant circuit. If the regurgitant valve flow was large enough, it in turn affected the function of the left ventricle. The present investigation suggests that many features observed in patients with mitral or aortic regurgitation can be qualitatively satisfactorily simulated. In some respects even quantitative simulation is possible. However, for simulation of chronic mitral or aortic regurgitation, in the analog electronic circuit additional adjustments-in capacitance of the left ventricle and pulmonary system--would be required.
J Dolensek; T Podnar; F Runovc; M Kordas
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Publication Detail:
Type:  Journal Article     Date:  2009-04-21
Journal Detail:
Title:  Computers in biology and medicine     Volume:  39     ISSN:  1879-0534     ISO Abbreviation:  Comput. Biol. Med.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1250250     Medline TA:  Comput Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  474-81     Citation Subset:  IM    
Institute of Anatomy, Faculty of Medicine, University of Ljubljana, 1106 Ljubljana, Slovenia.
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MeSH Terms
Aortic Valve / physiology,  physiopathology
Aortic Valve Insufficiency / physiopathology*
Blood Pressure / physiology
Computer Simulation*
Coronary Circulation / physiology
Diastole / physiology
Heart / physiology,  physiopathology
Mitral Valve / physiology,  physiopathology
Mitral Valve Insufficiency / physiopathology*
Models, Cardiovascular*
Systole / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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