Document Detail

Analgesic properties of valproic acid might be related to activation of pro-enkephalin system in rat brain.
MedLine Citation:
PMID:  3109687     Owner:  NLM     Status:  MEDLINE    
Recent in vivo and in vitro studies have shown the involvement of gamma-aminobutyric acid (GABA) in analgesia. We investigated if the analgesia induced by an acute valproic acid (VPA) administration might be related to the activation of the enkephalinergic system. VPA administration (i.p.) induces 30 min after treatment a significant and dose-dependent increase of Leu-enkephalin and Met-enkephalin in the striatum, hypothalamus, cortex and brainstem. In the hypophysis no modification was observed for these two neuropeptides. The Met-enkephalin-Arg-Gly-Leu levels are affected by VPA administration in a more complex pattern. Such results suggest the implication of an enkephalinergic system in GABAergic analgesia.
J Vion-Dury; A Cupo; T Jarry
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  408     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-30     Completed Date:  1987-07-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  243-6     Citation Subset:  IM    
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MeSH Terms
Brain Chemistry / drug effects*
Enkephalin, Leucine / metabolism*
Enkephalin, Methionine / analogs & derivatives,  metabolism*
Rats, Inbred Strains
Valproic Acid / pharmacology*
Reg. No./Substance:
0/Analgesics; 58569-55-4/Enkephalin, Methionine; 58822-25-6/Enkephalin, Leucine; 80501-44-6/enkephalin-Met, Arg(6)-Gly(7)-Leu(8)-; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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