| Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats. | |
| | |
MedLine Citation:
|
PMID: 22326968 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Ras and c-Raf constitute an important part of mitogen-activated protein (MAP) kinase family as Ras/Raf/MEK/ERK2 signaling cascade and the role of MAP kinases has been well defined in neuropathic pain. The present study investigates the analgesic potential of farnesyl thiosalicylic acid, a novel Ras inhibitor, and GW 5074, a selective c-Raf1 inhibitor, in vincristine-induced neuropathic pain. Peripheral neuropathy was induced in rats by administering vincristine (50μg/kg i.p.) for 10consecutive days. Pain development was assessed on 14th day in terms of cold allodynia; mechanical hyperalgesia and mechanical allodynia by performing acetone test, pin-prick and von frey tests, respectively. Farnesyl thiosalicylic acid and GW 5074 were injected intrathecally on 14th day following vincristine administration. Administration of vincristine produced significant neuropathic pain manifestations in terms of cold and mechanical allodynia, and mechanical hyperalgesia. Single intrathecal administration of farnesyl thiosalicylic acid (5 and 10μg) as well as GW 5074 (2 and 4μg) significantly attenuated vincristine-induced hyperalgesia and allodynia. The analgesic effects of farnesyl thiosalicylic acid and GW 5074 in vincristine model suggests that pharmacological inhibition of Ras and c-Raf-1 signalling may be potentially useful for managing neuropathic pain. |
| | |
Authors:
|
Amteshwar Singh Jaggi; Nirmal Singh |
Related Documents
:
|
22664778 - Effects of general anesthetics on p2x4 receptors in a mouse microglial cell line. 22469638 - Interaction of fentanyl and buprenorphine in an experimental model of pain and central ... 22647428 - White matter brain and trigeminal nerve abnormalities in temporomandibular disorder. 22500608 - Serotonin-induced hypersensitivity via inhibition of catechol o-methyltransferase activ... 16931688 - Imaging pain modulation by subanesthetic s-(+)-ketamine. 20609128 - Differences in brain structure and function in older adults with self-reported disablin... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-4 |
Journal Detail:
|
Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: - ISSN: 1873-6351 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
|
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glutamate transporters control metabotropic glutamate receptors activation to prevent the genesis of...
Next Document: Mechanism of cisplatin resistance in human urothelial carcinoma cells.