Document Detail

Analgesic nephropathy. Clinical course after withdrawal of phenacetin.
MedLine Citation:
PMID:  5797777     Owner:  NLM     Status:  MEDLINE    
Of 14 patients with analgesic nephropathy 11 were followed up for 9 to 88 (mean 36) months after withdrawal of analgesics containing phenacetin. Ten of these 11 are still alive and have improving, static, or very slowly declining renal function. Analgesic withdrawal is therefore worth achieving even in the presence of advanced renal failure. Careful prolonged follow-up is required to prevent or detect relapse and to deal with the complications of prolonged renal failure, particularly bone disease and acidosis.Early diagnosis is life-saving in this condition. Attention is drawn to the diagnostic value of sterile pyuria, but the best screening test for the condition is careful interrogation of all patients with chronic renal disease of unknown aetiology; analgesic intake is rarely denied if asked for specifically.
D Bell; D N Kerr; J Swinney; W K Yeates
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  3     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1969 Aug 
Date Detail:
Created Date:  1969-09-09     Completed Date:  1969-09-09     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  378-82     Citation Subset:  AIM; IM    
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MeSH Terms
Acidosis, Renal Tubular / etiology
Analgesics / adverse effects*
Bone Diseases / etiology
Follow-Up Studies
Kidney Failure, Chronic / chemically induced*,  complications,  diagnosis
Middle Aged
Phenacetin / adverse effects*
Reg. No./Substance:
0/Analgesics; 62-44-2/Phenacetin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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