Document Detail

Analgesic effects of rofecoxib in ear-nose-throat surgery.
MedLine Citation:
PMID:  12401617     Owner:  NLM     Status:  MEDLINE    
IMPLICATIONS: The aim of this study was to evaluate the analgesic efficacy and opioid-sparing effect of rofecoxib, a new selective cyclooxygenase-2 inhibitor drug, in ear-nose-throat surgery patients. Preoperative administration of oral rofecoxib provided a significant analgesic benefit and decreased the need for opioids in patients undergoing nasal septal and nasal sinus surgery.
A Turan; S Emet; B Karamanlioğlu; D Memiş; N Turan; Z Pamukcu
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  95     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-28     Completed Date:  2002-11-19     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1308-11, table of contents     Citation Subset:  AIM; IM    
Department of Anaesthesiology, Trakya University Medical Faculty, 22030 Edirne, Turkey.
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MeSH Terms
Analgesics, Opioid / therapeutic use
Anesthetics, Local / therapeutic use
Blood Pressure / drug effects
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors / therapeutic use*
Double-Blind Method
Fentanyl / therapeutic use
Heart Rate / drug effects
Isoenzymes / metabolism*
Lactones / therapeutic use*
Lidocaine / therapeutic use
Membrane Proteins
Otorhinolaryngologic Surgical Procedures*
Oxygen / blood
Pain Measurement / drug effects
Pain, Postoperative / drug therapy*
Prospective Studies
Prostaglandin-Endoperoxide Synthases / metabolism*
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anesthetics, Local; 0/Cyclooxygenase 2 Inhibitors; 0/Cyclooxygenase Inhibitors; 0/Isoenzymes; 0/Lactones; 0/Membrane Proteins; 0/Sulfones; 0/rofecoxib; 137-58-6/Lidocaine; 437-38-7/Fentanyl; 7782-44-7/Oxygen; EC 2; EC protein, human; EC Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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