| Analgesic effects of diclofenac suppository and injection after preoperative administration. | |
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MedLine Citation:
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PMID: 10669898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diclofenac sodium (100 mg) has been introduced in the Caribbean as a suppository formulation. In a randomized single-blind (observer-blind) clinical trial, the postoperative analgesic efficacy of diclofenac administered either as a conventional intramuscular injection (75 mg) or as the available suppository formulation (100 mg) was studied in 44 adult male patients undergoing herniorrhaphy in same day surgery. Diclofenac was administered preoperatively at induction of anesthesia to patients (grades ASA I and II) after they had given informed consent. Evaluation of analgesia on the visual analog scale (VAS) did not differ significantly between the two treated groups at three assessment times: on admission to the recovery room, the postoperative ward and at discharge. The times for requests for additional analgesia and the number of patients requesting further analgesia did not differ. Patients who received the suppository were discharged earlier than those who received the injection (40 min vs. 65 min p = 0.02). This preliminary study of the two marketed formulations of diclofenac demonstrated that both preparations provided equivalent analgesia but patients who received the suppository preparation were discharged earlier. |
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Authors:
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L M Pinto Pereira; D Chen; Y Clement; D Simeon |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: International journal of clinical pharmacology research Volume: 19 ISSN: 0251-1649 ISO Abbreviation: Int J Clin Pharmacol Res Publication Date: 1999 |
Date Detail:
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Created Date: 2000-02-25 Completed Date: 2000-02-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110183 Medline TA: Int J Clin Pharmacol Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 47-51 Citation Subset: IM |
Affiliation:
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Department of Paraclinical Sciences, University of the West Indies, Trinidad, West Indies. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analgesics / administration & dosage Diclofenac / administration & dosage* Hernia / surgery Humans Injections, Intramuscular Length of Stay Male Middle Aged Postoperative Period Preoperative Care Single-Blind Method Suppositories Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Suppositories; 15307-86-5/Diclofenac |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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