Document Detail

Analgesic-antipyretic drugs as inhibitors of kallikrein.
MedLine Citation:
PMID:  13729628     Owner:  NLM     Status:  MEDLINE    
The production of kallidin from guinea-pig and ox serum kallidinogen by the action of guinea-pig serum-kallikrein or human salivary kallikrein was inhibited by various analgesic-antipyretic drugs. This effect was obtained in vitro with concentrations of inhibitors which do not inhibit the smooth-muscle-stimulating action of the various polypeptides, but similar to the concentrations needed in vivo to obtain an anti-inflammatory action. The vasodepressor action of intravenously administered human salivary kallikrein in the anaesthetized dog was very markedly inhibited by the intravenous administration of doses of various analgesic-antipyretic drugs which only partially antagonized the responses to kallidin and bradykinin and which left the vasodepressor responses to histamine, acetylcholine and 5-hydroxytryptamine unaffected. In rabbits the accumulation of protein-bound dye at the site of intradermal injection of human salivary kallikrein and guinea-pig serum-kallikrein, but not of bradykinin and kallidin, was inhibited very markedly by the systemic administration of various analgesic-antipyretic drugs.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology and chemotherapy     Volume:  17     ISSN:  0366-0826     ISO Abbreviation:  Br J Pharmacol Chemother     Publication Date:  1961 Aug 
Date Detail:
Created Date:  1961-12-01     Completed Date:  1998-11-01     Revised Date:  2012-04-16    
Medline Journal Info:
Nlm Unique ID:  0154627     Medline TA:  Br J Pharmacol Chemother     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  107-15     Citation Subset:  OM    
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MeSH Terms
Analgesics, Non-Narcotic / pharmacology*
Kallikreins / antagonists & inhibitors*
Reg. No./Substance:
0/Analgesics, Non-Narcotic; EC 3.4.21.-/Kallikreins

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