Document Detail

Analgesic and antiinflammatory activity screening of 6-acyl-3-piperidinomethyl-2(3H)-benzoxazolone derivatives.
MedLine Citation:
PMID:  7826474     Owner:  NLM     Status:  MEDLINE    
6-Acetyl-2(3H)-benzoxazolone derivatives were reacted with appropriate piperidine derivatives and formaldehyde in methanol to give the corresponding 6-acyl-3-piperidinomethyl-2(3H)-benzoxazolones. The obtained compounds were screened for their analgesic and antiinflammatory activities. Analgesic activity of these compounds was investigated by modified Koster test. Antiinflammatory activity was assayed by using carrageenan induced mouse paw edema test and arachidonic acid edema. The 15 compounds synthesized showed good analgesic activities; compounds 1,3 and 6 moved to be active inhibitors of edema.
D D Erol; R Demirdamar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Farmaco (Società chimica italiana : 1989)     Volume:  49     ISSN:  0014-827X     ISO Abbreviation:  Farmaco     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-02-23     Completed Date:  1995-02-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8912641     Medline TA:  Farmaco     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  663-6     Citation Subset:  IM    
Hacettepe University, Faculty of Pharmacy Pharmaceutical Chemistry Department, Sihhiye-Ankara/Turkey.
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MeSH Terms
Analgesics / chemical synthesis*,  pharmacology
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*,  pharmacology
Benzoxazoles / chemical synthesis*,  pharmacology
Reg. No./Substance:
0/Analgesics; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Benzoxazoles; 59-49-4/benzoxazolone

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