| Analgesic and antiinflammatory activity of methanolic extract of Acalypha indica Linn. | |
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MedLine Citation:
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PMID: 20566436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous phytochemical analysis of methanolic extract of Acalypha indica L. has indicated the presence of steroid, flavonoid and terpenoid types of compounds. Since these compounds are of pharmacological interest, coupled with the use of this plant in traditional medicine, prompted us to check A. indica L. for possible analgesic and antiinflammatory activities. The methanolic extract of A. indica L. showed statistically significant (p<0.001) analgesic activity in mice in a dose-dependent manner. A sustained and significant (p<0.001) inhibition of carrageenan-induced inflammation of rat paw was observed with 125 mg/kg and 250 mg/kg body weight. The methanolic extract of A. indica L. also demonstrated antiinflammatory effect in a dose-dependent manner. Maximum inhibition by the extract was observed at 250 mg/kg body weight after three hours of ingestion, which was comparable to that of the standard drug phenylbutazone at a dose of 100 mg/kg body weight. The obtained results provide a support for the use of this plant in traditional medicine. |
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Authors:
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M Aminur Rahman; Sitesh C Bachar; Mohammed Rahmatullah |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pakistan journal of pharmaceutical sciences Volume: 23 ISSN: 1011-601X ISO Abbreviation: Pak J Pharm Sci Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426356 Medline TA: Pak J Pharm Sci Country: Pakistan |
Other Details:
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Languages: eng Pagination: 256-8 Citation Subset: IM |
Affiliation:
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Department of Biotechnology and Genetic Engineering, University of Development Alternative, House No. 78, Road No. 11A, Dhanmondi, Dhaka-1205, Bangladesh. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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pharmacology* Animals Anti-Inflammatory Agents / pharmacology* Euphorbiaceae / chemistry* Female Male Mice Plant Extracts / pharmacology* Rats Rats, Long-Evans |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Anti-Inflammatory Agents; 0/Plant Extracts |
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