| Analgesic, anti-inflammatory, and CNS depressant activities of new constituents of Nepeta clarkei. | |
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MedLine Citation:
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PMID: 22266390 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Two new pentacyclic triterpenes named kirmanoic acid (1) and kurramanoic acid (2) have been isolated from the chloroform-soluble portion of the whole plant of Nepeta clarkei Hook. The structures of the two new compounds were assigned on the basis of their (1)H and (13)C NMR spectra including two-dimensional NMR techniques such as COSY, HMQC, and HMBC experiments. Kirmanoic acid (1) was investigated for analgesic, anti-inflammatory, and CNS depressant activities. Interestingly kirmanoic acid (1) showed strong analgesic activity than standard drug in acetic induced writhing and formalin tests. Similarly kirmanoic acid (1) also showed strong anti-inflammatory activity than its standard drug. The gross behavioral study of kirmanoic acid (1) revealed that it exhibited mild CNS stimulant and muscle relaxant in the mice. Compound 1 showed a slight increase in Locomotor activity and possesses the antidepressant effect. |
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Authors:
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Javid Hussain; Najeeb Ur Rehman; Hidayat Hussain; Ahmed Al-Harrasi; Liaqat Ali; Tania Shamim Rizvi; Mansoor Ahmad; Mehjabeen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-14 |
Journal Detail:
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Title: Fitoterapia Volume: - ISSN: 1873-6971 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Department of Chemistry, Kohat University of Science and Technology, Kohat, Khyber Pakhtunkhwa, Pakistan; Department of Biological Sciences and Chemistry, College of Arts and Sciences University of Nizwa, Oman. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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