Document Detail

Analgesic action of methylphenidate on parkinsonian sensory symptoms. Mechanisms and pathophysiological implications.
MedLine Citation:
PMID:  2458094     Owner:  NLM     Status:  MEDLINE    
Intravenous administration of methylphenidate hydrochloride, a central stimulant, was unexpectedly found to exert a potent analgesic effect on primary sensory symptoms in a group of patients with Parkinson's disease. This effect, which has now been studied in a short-term, double-blind, placebo-controlled experiment, subsequently disappeared if patients were pretreated with a beta-blocker or with a serotonin antagonist. Cerebrospinal fluid monoamine metabolites were determined in some of these patients, and the 5-hydroxyindoleacetic acid level was found to be significantly lower than in parkinsonian patients without pain and in normal volunteers. Given the mechanism of action of methylphenidate on the central nervous system, the adrenergic and serotoninergic mediation of its analgesic effect, and the demonstration of impaired central serotonin metabolism in the patient group, it is concluded that not only central dopaminergic deficiency but also altered noradrenergic and serotoninergic transmission in the spinal cord are quite likely to play a role in the pathophysiology of pain in Parkinson's disease.
R Cantello; M Aguggia; M Gilli; M Delsedime; A Riccio; I Rainero; R Mutani
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  45     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-09-29     Completed Date:  1988-09-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  973-6     Citation Subset:  AIM; IM    
Department of Neurology, University School of Medicine, Turin, Italy.
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MeSH Terms
Analgesics / therapeutic use*
Biogenic Amines / cerebrospinal fluid
Methylphenidate / antagonists & inhibitors,  therapeutic use*
Methysergide / pharmacology
Middle Aged
Palliative Care*
Parkinson Disease / cerebrospinal fluid,  drug therapy*,  physiopathology
Propranolol / pharmacology
Reg. No./Substance:
0/Analgesics; 0/Biogenic Amines; 113-45-1/Methylphenidate; 361-37-5/Methysergide; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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