| Analgesic and antiallodynic effects of antidepressants after infiltration into the rat. | |
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MedLine Citation:
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PMID: 20829646 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Tricyclic antidepressants (TCA) have potent local anesthetic properties and may produce a long-lasting pain blockade that could be of interest in relieving chronic pain states such as neuropathic pain, but there are only few data comparing their dose-response curves of analgesic activity under the same experimental conditions. This study examines the time course of pain-relieving properties of 7 TCA in heat-induced paw withdrawal after subcutaneous administration. Mixed inhibitors of norepinephrine and serotonin uptake (amitriptyline, nortriptyline, imipramine, desipramine, doxepin) and selective inhibitors of serotonin uptake (fluoxetine and fluvoxamine) were assayed. The TCA with the longest analgesic activity were selected to test its antiallodynic effect in the neuropathic pain model of chronic sciatic nerve constriction injury. Bupivacaine was used as a reference drug in both experiments. A dose versus time of maximal analgesic effect curve was constructed for each drug. The longest analgesic effect was obtained for doxepin and imipramine. Although low doses of amitriptyline showed the same activity than doxepin, higher doses failed to reach the same effect. Selective inhibitors of serotonin showed no action at all doses tested. In the chronic sciatic nerve constriction injury model, doxepin and, to a smaller degree, amitriptyline and imipramine protected from allodynia; bupivacaine was ineffective. The antiallodynic effect always lasted less long than the analgesic effect. These observations provide support for the potential use of TCA as durable analgesics. Doxepin overall showed the most outstanding results in pain relief. |
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Authors:
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Xavier Garcia; Jaume del Valle; Elvira Escribano; Josep Domenech; Josep Queralt |
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Publication Detail:
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Type: Journal Article Date: 2010-09-09 |
Journal Detail:
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Title: Pharmacology Volume: 86 ISSN: 1423-0313 ISO Abbreviation: Pharmacology Publication Date: 2010 |
Date Detail:
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Created Date: 2010-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0152016 Medline TA: Pharmacology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 216-23 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Pharmacy and Pharmaceutical Technology, Biopharmaceuticals and Pharmacokinetics Unit, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain. xavier.garcia @ ipsen.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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