| Analgesia with sevoflurane during labour: ii. Sevoflurane compared with Entonox for labour analgesia. | |
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MedLine Citation:
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PMID: 17158129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We determined the optimal inspired sevoflurane concentration for use during labour as 0.8% in our previous study. This study compared sevoflurane at a concentration of 0.8% and Entonox((R)) (nitrous oxide 50%: oxygen 50%) for analgesia during labour in 32 healthy parturients. METHODS: Each mother underwent two open-label, three-part sequences in random order, Entonox-sevoflurane-Entonox or sevoflurane-Entonox-sevoflurane. In each part the agent was self-administered during 10 contractions. A 100 mm visual analogue scores for pain relief and sedation was completed immediately after each contraction. RESULTS: Two patients withdrew during administration of sevoflurane (because of its odour) and five during Entonox (requesting epidural analgesia). Of the remaining women, data were available for analysis from 29 participants: median (IQR [range]) pain relief scores were significantly higher for sevoflurane 67 (55-74 [33-100]) mm than for Entonox 51 (40-69.5 [13-100]) mm (P<0.037). Nausea and vomiting were more common in the Entonox group [relative risk 2.7 (95% CI 1.3-5.7); P=0.004]. No other adverse effects were observed in the mothers or babies. There was significantly more sedation with sevoflurane than with Entonox {74 (66.5-81 [32.5-100]) and 51 (41-69.5 [13-100]) mm, respectively; P<0.001}. Twenty-nine patients preferred sevoflurane to Entonox and found its sedative effects helpful. CONCLUSIONS: We conclude that self-administered sevoflurane at subanaesthetic concentration (0.8%) can provide useful pain relief during the first stage of labour, and to a greater extent than Entonox. Although greater sedative effects were experienced with sevoflurane, it was preferred to Entonox. |
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Authors:
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S T Yeo; A Holdcroft; S M Yentis; A Stewart; P Bassett |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of anaesthesia Volume: 98 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-12 Completed Date: 2007-02-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 110-5 Citation Subset: IM |
Affiliation:
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Magill Department of Anaesthesia, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK. sengyeo@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analgesia, Obstetrical / adverse effects, methods* Analgesia, Patient-Controlled / methods Anesthetics, Inhalation / administration & dosage*, adverse effects Conscious Sedation Cross-Over Studies Drug Combinations Female Humans Methyl Ethers / administration & dosage*, adverse effects Nausea / chemically induced Nitrous Oxide / administration & dosage*, adverse effects Oxygen / administration & dosage*, adverse effects Pain Measurement / methods Patient Satisfaction Pregnancy Vomiting / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Drug Combinations; 0/Methyl Ethers; 10024-97-2/Nitrous Oxide; 28523-86-6/sevoflurane; 54510-89-3/Entonox; 7782-44-7/Oxygen |
| Comments/Corrections | |
Comment In:
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Br J Anaesth. 2007 Jan;98(1):1-2
[PMID:
17158124
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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