| Analgesia and sedation in neonatal intensive care using fentanyl by continuous infusion. | |
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MedLine Citation:
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PMID: 1841826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the effects of fentanyl in newborn and premature infants, we compared two groups of 20 newborn and premature babies under artificial ventilation for severe respiratory distress syndrome: a prospective group receiving fentanyl for analgesic and sedation and a historical control group, who did not receive fentanyl. Fentanyl serum levels during steady state were determined by radioimmunoassay. Average time of infusion was 86 +/- 47 h with a mean dosage of 0.68 +/- 0.24 micrograms/kg/h. The fentanyl group needed much less sedatives and catecholamines. Heart rate and blood pressure were not significantly changed by fentanyl. Meconium was excreted later, and higher values of bilirubin were reached earlier than in the control group. Although fentanyl proved to be helpful in the neonatal intensive care unit, the administration should remain under strict indication. |
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Authors:
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B Roth; C Schlünder; F Houben; M Günther; M Theisohn |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental pharmacology and therapeutics Volume: 17 ISSN: 0379-8305 ISO Abbreviation: Dev Pharmacol Ther Publication Date: 1991 |
Date Detail:
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Created Date: 1992-12-03 Completed Date: 1992-12-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8003947 Medline TA: Dev Pharmacol Ther Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 121-7 Citation Subset: IM |
Affiliation:
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Children's Hospital, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bilirubin
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blood Blood Pressure / drug effects Female Fentanyl / administration & dosage* Gestational Age Heart Rate / drug effects Humans Hypnotics and Sedatives* / administration & dosage Infant, Newborn / physiology* Infant, Premature / physiology* Infusions, Intravenous Male Respiration, Artificial |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 437-38-7/Fentanyl; 635-65-4/Bilirubin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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