Document Detail

Analgesia and sedation in neonatal intensive care using fentanyl by continuous infusion.
MedLine Citation:
PMID:  1841826     Owner:  NLM     Status:  MEDLINE    
To determine the effects of fentanyl in newborn and premature infants, we compared two groups of 20 newborn and premature babies under artificial ventilation for severe respiratory distress syndrome: a prospective group receiving fentanyl for analgesic and sedation and a historical control group, who did not receive fentanyl. Fentanyl serum levels during steady state were determined by radioimmunoassay. Average time of infusion was 86 +/- 47 h with a mean dosage of 0.68 +/- 0.24 micrograms/kg/h. The fentanyl group needed much less sedatives and catecholamines. Heart rate and blood pressure were not significantly changed by fentanyl. Meconium was excreted later, and higher values of bilirubin were reached earlier than in the control group. Although fentanyl proved to be helpful in the neonatal intensive care unit, the administration should remain under strict indication.
B Roth; C Schlünder; F Houben; M Günther; M Theisohn
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  17     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1991  
Date Detail:
Created Date:  1992-12-03     Completed Date:  1992-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  121-7     Citation Subset:  IM    
Children's Hospital, FRG.
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MeSH Terms
Bilirubin / blood
Blood Pressure / drug effects
Fentanyl / administration & dosage*
Gestational Age
Heart Rate / drug effects
Hypnotics and Sedatives* / administration & dosage
Infant, Newborn / physiology*
Infant, Premature / physiology*
Infusions, Intravenous
Respiration, Artificial
Reg. No./Substance:
0/Hypnotics and Sedatives; 437-38-7/Fentanyl; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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