Document Detail


Analgesia accompanying food consumption requires ingestion of hedonic foods.
MedLine Citation:
PMID:  19828818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Animals eat rather than react to moderate pain. Here, we examined the behavioral, hedonic, and neural requirements for ingestion analgesia in ad libitum fed rats. Noxious heat-evoked withdrawals were similarly suppressed during self-initiated chocolate eating and ingestion of intraorally infused water, sucrose, or saccharin, demonstrating that ingestion analgesia does not require feeding motivation, self-initiated food procurement, sucrose, or calories. Rather, food hedonics is important because neither salt ingestion nor quinine rejection elicited analgesia. During quinine-induced nausea and lipopolysaccharide (LPS)-induced illness, conditions when chocolate eating was presumably less pleasurable, analgesia accompanying chocolate consumption was attenuated, yet analgesia during water ingestion was preserved in LPS-injected rats who showed enhanced palatability for water within this context. The dependence of ingestion analgesia on the positive hedonics of an ingestate was confirmed in rats with a conditioned taste aversion to sucrose: after paired exposure to sucrose and LPS, rats no longer showed analgesia during sucrose ingestion but continued to show analgesia during chocolate consumption. Eating pauses tended to occur less often and for shorter durations in the presence of ingestion analgesia than in its absence. Therefore, we propose that ingestion analgesia functions to defend eating from ending. Muscimol inactivation of the medullary raphe magnus blocked the analgesia normally observed during water ingestion, showing the involvement of brainstem endogenous pain inhibitory mechanisms in ingestion analgesia. Brainstem-mediated defense of the consumption of palatable foods may explain, at least in part, why overeating tasty foods is so irresistible even in the face of opposing cognitive and motivational forces.
Authors:
H Foo; Peggy Mason
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  29     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-15     Completed Date:  2009-10-30     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13053-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analgesia*
Analgesics, Non-Narcotic / administration & dosage,  pharmacology
Analysis of Variance
Animals
Avoidance Learning / drug effects,  physiology
Behavior, Animal / drug effects,  physiology*
Cacao
Conditioning, Classical / drug effects,  physiology
Conditioning, Operant / drug effects,  physiology
Eating / drug effects,  physiology*
Electromyography / methods
Feeding Behavior / drug effects,  physiology*
Food Preferences / drug effects,  physiology*
Hot Temperature / adverse effects
Hypnotics and Sedatives / pharmacology
Lipopolysaccharides / pharmacology
Male
Pentobarbital / pharmacology
Quinine / administration & dosage
Rats
Rats, Sprague-Dawley
Reaction Time / drug effects
Sweetening Agents / administration & dosage,  pharmacology
Grant Support
ID/Acronym/Agency:
R01 DA022978/DA/NIDA NIH HHS; R01 DA022978-06A1/DA/NIDA NIH HHS; R01 DA022978-07/DA/NIDA NIH HHS; R01 DA022978-08/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Hypnotics and Sedatives; 0/Lipopolysaccharides; 0/Sweetening Agents; A7V27PHC7A/Quinine; I4744080IR/Pentobarbital
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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