| Analgesia accompanying food consumption requires ingestion of hedonic foods. | |
| | |
MedLine Citation:
|
PMID: 19828818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Animals eat rather than react to moderate pain. Here, we examined the behavioral, hedonic, and neural requirements for ingestion analgesia in ad libitum fed rats. Noxious heat-evoked withdrawals were similarly suppressed during self-initiated chocolate eating and ingestion of intraorally infused water, sucrose, or saccharin, demonstrating that ingestion analgesia does not require feeding motivation, self-initiated food procurement, sucrose, or calories. Rather, food hedonics is important because neither salt ingestion nor quinine rejection elicited analgesia. During quinine-induced nausea and lipopolysaccharide (LPS)-induced illness, conditions when chocolate eating was presumably less pleasurable, analgesia accompanying chocolate consumption was attenuated, yet analgesia during water ingestion was preserved in LPS-injected rats who showed enhanced palatability for water within this context. The dependence of ingestion analgesia on the positive hedonics of an ingestate was confirmed in rats with a conditioned taste aversion to sucrose: after paired exposure to sucrose and LPS, rats no longer showed analgesia during sucrose ingestion but continued to show analgesia during chocolate consumption. Eating pauses tended to occur less often and for shorter durations in the presence of ingestion analgesia than in its absence. Therefore, we propose that ingestion analgesia functions to defend eating from ending. Muscimol inactivation of the medullary raphe magnus blocked the analgesia normally observed during water ingestion, showing the involvement of brainstem endogenous pain inhibitory mechanisms in ingestion analgesia. Brainstem-mediated defense of the consumption of palatable foods may explain, at least in part, why overeating tasty foods is so irresistible even in the face of opposing cognitive and motivational forces. |
| | |
Authors:
|
H Foo; Peggy Mason |
Related Documents
:
|
19433008 - Eating out of home and obesity: a brazilian nationwide survey. 10102218 - Biliopancreatic diversion (doudenal switch procedure). 20095978 - Brain electrical activity during food presentation in obese binge-eating women. 9716438 - "extravagances" during weight reduction, an analysis of food preference and selection. 22433078 - Determination of 15 isoflavone isomers in soy foods and supplements by high-performance... 18671918 - Glucose can reverse the effects of acute fasting on mouse ovulation and oocyte maturation. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 29 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-10-15 Completed Date: 2009-10-30 Revised Date: 2011-05-04 |
Medline Journal Info:
|
Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
|
Languages: eng Pagination: 13053-62 Citation Subset: IM |
Affiliation:
|
Department of Neurobiology and Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analgesia* Analgesics, Non-Narcotic / administration & dosage, pharmacology Analysis of Variance Animals Avoidance Learning / drug effects, physiology Behavior, Animal / drug effects, physiology* Cacao Conditioning, Classical / drug effects, physiology Conditioning, Operant / drug effects, physiology Eating / drug effects, physiology* Electromyography / methods Feeding Behavior / drug effects, physiology* Food Preferences / drug effects, physiology* Hot Temperature / adverse effects Hypnotics and Sedatives / pharmacology Lipopolysaccharides / pharmacology Male Pentobarbital / pharmacology Quinine / administration & dosage Rats Rats, Sprague-Dawley Reaction Time / drug effects Sweetening Agents / administration & dosage, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
|
R01 DA022978-06A1/DA/NIDA NIH HHS; R01 DA022978-07/DA/NIDA NIH HHS; R01 DA022978-08/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Analgesics, Non-Narcotic; 0/Hypnotics and Sedatives; 0/Lipopolysaccharides; 0/Sweetening Agents; 130-95-0/Quinine; 76-74-4/Pentobarbital |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: {gamma}-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of {...
Next Document: Bestrophin-1 encodes for the Ca2+-activated anion channel in hippocampal astrocytes.