| Anal squamous carcinoma: a new AIDS-defining cancer? Case report and literature review. | |
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MedLine Citation:
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PMID: 23152321 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Squamous anal cell carcinoma is a rare malignancy that represents the 1.5% to 2% of all the lower digestive tract cancers. However, an increased incidence of invasive anal carcinoma is observed in HIV-seropositive population since the widespread of highly active antiretroviral therapy. Human papillomavirus is strongly associated with the pathogenesis of anal cancer. Anal intercourse and a high number of sexual partners appear to be risk factors to develop anal cancer in both sexes. Anal pain, bleeding and a palpable lesion in the anal canal are the most common clinical features. Endo-anal ultrasound is the best diagnosis method to evaluate the tumor size, the tumor extension and the infiltration of the sphincter muscle complex. Chemoradiotherapy plus antiretroviral therapy are the recommended treatments for all stages of localized squamous cell carcinoma of the anal canal in HIV-seropositive patients because of its high rate of cure. Here we present an HIV patient who developed a carcinoma of the anal canal after a long time of HIV infection under highly active antiretroviral therapy with a good virological and immunological response. |
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Authors:
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Marcelo Corti; María F Villafañe; Esteban Marona; Daniel Lewi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Revista do Instituto de Medicina Tropical de São Paulo Volume: 54 ISSN: 1678-9946 ISO Abbreviation: Rev. Inst. Med. Trop. Sao Paulo Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7507484 Medline TA: Rev Inst Med Trop Sao Paulo Country: Brazil |
Other Details:
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Languages: eng Pagination: 345-8 Citation Subset: IM |
Affiliation:
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Division of HIV/AIDS, Infectious Diseases F. J. Muñiz Hospital, Buenos Aires, Argentina. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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