| Anal incontinence improvement after silicone injection may be related to restoration of sphincter asymmetry. | |
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MedLine Citation:
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PMID: 19546122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study aimed to evaluate manometric parameters that may explain improvement in anal incontinence using a silicone bulking agent. METHODS: Incontinent patients having internal sphincter defects were prospectively selected and injected with a silicone bulking agent. Manometry and endoanal ultrasound were performed before and 3 months after injections. Twenty continent healthy volunteers were used only for manometric comparison. RESULTS: Thirty-five patients (28 females; mean age 60.3 years) and 20 controls entered this study. Patients had lower resting and squeeze pressures compared with controls (P < .05). Length of the high-pressure zone increased from 1 to 1.7 cm postinjection (P = .002). Asymmetry index showed a significant change postinjection (P < .001). CONCLUSION: Despite considerable clinical improvement, no significant increase in manometric pressures was noted posttreatment. There was significant improvement in both high-pressure zone and asymmetry index, and these findings may explain the mechanism of action of the bulking agent injected. |
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Authors:
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Lucia C C Oliveira; José Marcio Neves Jorge; Sonia Yussuf; Angelita Habr-Gama; Desidério Kiss; Ivan Cecconello |
Publication Detail:
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Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Surgical innovation Volume: 16 ISSN: 1553-3506 ISO Abbreviation: - Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-23 Completed Date: 2009-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233809 Medline TA: Surg Innov Country: United States |
Other Details:
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Languages: eng Pagination: 155-61 Citation Subset: IM |
Affiliation:
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Department of Anorectal Physiology, Policlínica Geral do Rio de Janeiro, Rio de Janeiro, Brazil. dralucia@uninet.com.br |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anal Canal / pathology, physiopathology*, ultrasonography Biocompatible Materials / administration & dosage* Cohort Studies Endosonography Fecal Incontinence / etiology, physiopathology*, therapy* Female Humans Injections Male Manometry Middle Aged Quality of Life Silicones / administration & dosage* Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Silicones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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