Document Detail

Anal fistula plug vs mucosa advancement flap in complex fistula-in-ano: A meta-analysis.
MedLine Citation:
PMID:  23494149     Owner:  NLM     Status:  PubMed-not-MEDLINE    
AIM: To investigate the efficacy of the anal fistula plug (AFP) compared to the mucosa advancement flap (MAF), considered the best procedure for patients with a complex anal fistula.
METHODS: The literature search included PubMed, EMBASE, Cochrane Library and OVID original studies on the topic of AFP compared to MAF for complex fistula-in-ano that had a deadline for publication by April 2011. Randomized controlled trials, controlled clinical trials and prospective cohort studies were included in the review. After information collection, a meta-analysis was performed using data on overall success rates as well as incidence of incontinence and morbidity. The quality of postoperative life was also included with the clinical results.
RESULTS: Six studies involving 408 patients (AFP = 167, MAF = 241) were included in the meta-analysis. The differences in the overall success rates and incidence of fistula recurrence were not statistically significant between the AFP and MAF [risk difference (RD) = -0.12, 95%CI: -0.39 - 0.14; RD = 0.13; 95%CI: -0.18 - 0.43, respectively]. However, for the AFP, the risk of postoperative impaired continence was lower (RD = -0.08, 95%CI: -0.15 - -0.02) as was the incidence of other complications (RD = -0.06, 95%CI: -0.11 - -0.00). The postoperative quality of life, for patients treated using the AFP was superior to that of the MAF patients. Patients treated with the AFP had less persistent pain of a shorter duration and the healing time of the fistula and hospital stay were also reduced.
CONCLUSION: The AFP is an effective procedure for patients with a complex anal fistula; it has the same success rate but a lower risk of complications than the MAF and may also be associated with an improved postoperative quality of life. Additional evidence is needed to confirm these findings.
Qiang Leng; Hei-Ying Jin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastrointestinal surgery     Volume:  4     ISSN:  1948-9366     ISO Abbreviation:  World J Gastrointest Surg     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2013-03-15     Completed Date:  2013-03-18     Revised Date:  2013-03-18    
Medline Journal Info:
Nlm Unique ID:  101532473     Medline TA:  World J Gastrointest Surg     Country:  China    
Other Details:
Languages:  eng     Pagination:  256-61     Citation Subset:  -    
Qiang Leng, Hei-Ying Jin, National Center of Colorectal Surgery, the Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210001, Jiangsu Province, China.
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