Document Detail

Anal canal carcinoma with Pagetoid spread: report of a case.
MedLine Citation:
PMID:  16794808     Owner:  NLM     Status:  MEDLINE    
A 70-year-old man with a history of colon polyps was found to have a semipedunculated polyp in the anal canal. The patient was asymptomatic. The lesion was 14 mm in diameter and located 5 mm from the dentate line. Histological examination of biopsy specimens revealed well-differentiated adenocarcinoma of the anal canal. During transanal local excision of the tumor, an abnormality of the perianal skin was recognized. Although intraoperative frozen section of the perianal skin did not show malignancy, permanent sections of the perineal skin revealed Paget's cells in the epidermis. Pathological examination of the anal canal carcinoma revealed submucosally invasive well-differentiated adenocarcinoma with a positive distal surgical margin. Thus, we performed additional wide local excision of the perianal skin including the distal margin of the previous local excision. Pathological examination revealed continuance within the epidermis between the anal canal adenocarcinoma and Paget's cells in the perianal skin lesion. Scattered Paget's cells also formed some glandular structures. Thus, we concluded that the perianal skin lesion was Pagetoid spread of anal canal adenocarcinoma. This report shows that the perianal skin should be examined carefully in patients with anal canal carcinoma.
Mitsukuni Suenaga; Masatoshi Oya; Masashi Ueno; Jyunji Yamamoto; Toshiharu Yamaguchi; Nobuyuki Mizunuma; Kiyohiko Hatake; Yo Kato; Tetsuichiro Muto
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Surgery today     Volume:  36     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  2006  
Date Detail:
Created Date:  2006-06-23     Completed Date:  2007-02-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  666-9     Citation Subset:  IM    
Division of Gastroenterological Surgery, Ariake Cancer Institute Hospital, 3-10-6 Ariake, Tokyo, Japan.
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MeSH Terms
Anal Canal / pathology
Anus Neoplasms
Paget Disease Extramammary / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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