Document Detail

Anal mucosal melanoma with KIT-activating mutation and response to imatinib therapy--case report and review of the literature.
MedLine Citation:
PMID:  19996579     Owner:  NLM     Status:  MEDLINE    
Previously an increased frequency of KIT aberrations in mucosal melanomas was reported, whereas c-KIT in most types of cutaneous melanomas does not appear to be of pathogenetic importance. Imatinib has become the standard of care in other cancers with KIT mutations such as gastrointestinal stromal tumors. Recently 12 cases of metastatic melanoma and KIT-activating mutations have been published to be successfully treated with c-KIT blockers such as imatinib, sunitinib, dasatinib or sorafenib. We report here on one of our patients with KIT-activating mutation in metastatic anal mucosal melanoma, who showed a response to imatinib therapy and summarize the available literature regarding this new therapeutic option.
Imke Satzger; Uta K?ttler; Bernward V?lker; Florian Schenck; Alexander Kapp; Ralf Gutzmer
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2009-12-09
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  220     ISSN:  1421-9832     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-04-12     Revised Date:  2010-06-16    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  77-81     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Skin Cancer Center Hannover, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany. satzger.imke @
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MeSH Terms
Antineoplastic Agents / therapeutic use*
Anus Neoplasms / drug therapy*,  secondary
Melanoma / drug therapy*,  genetics,  secondary
Mucous Membrane / drug effects,  pathology
Piperazines / therapeutic use*
Protein Kinase Inhibitors / therapeutic use*
Proto-Oncogene Proteins c-kit / antagonists & inhibitors,  genetics
Pyrimidines / therapeutic use*
Skin Neoplasms / genetics,  pathology*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Piperazines; 0/Protein Kinase Inhibitors; 0/Pyrimidines; 152459-95-5/imatinib; EC Proteins c-kit

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