Document Detail


Anakinra (interleukin-1 receptor antagonist) has positive effects on function and quality of life in patients with rheumatoid arthritis.
MedLine Citation:
PMID:  16751154     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rheumatoid arthritis (RA) has severe and lasting effects on quality of life. This review (1) describes the disease progression, disability, and joint destruction that seriously alter a patient's quality of life, and (2) explains how the interleukin-1 receptor antagonist (IL-1Ra), anakinra, retards the progress of disease, thereby improving outcomes. Relevant articles were reviewed with a focus on RA, anakinra, and functional and quality-of-life outcomes. In randomized, controlled trials, the IL-1Ra anakinra provided meaningful benefits for patients with active RA, such as decreased signs and symptoms of disease, slower radiographic disease progression, reduced disability, and improved health-related quality of life. The biologic agent, anakinra, provides to patients with RA a valuable treatment option that has a positive impact on both function and quality of life.
Authors:
Arthur Kavanaugh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in therapy     Volume:  23     ISSN:  0741-238X     ISO Abbreviation:  Adv Ther     Publication Date:    2006 Mar-Apr
Date Detail:
Created Date:  2006-06-05     Completed Date:  2006-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8611864     Medline TA:  Adv Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  208-17     Citation Subset:  T    
Affiliation:
Center for Innovative Therapy, Division of Rheumatology, Allergy, and Immunology, University of California, San Diego, La Jolla, California 92093-0943, USA.
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MeSH Terms
Descriptor/Qualifier:
Antirheumatic Agents / administration & dosage,  therapeutic use*
Arthritis, Rheumatoid / drug therapy*,  psychology
Humans
Interleukin 1 Receptor Antagonist Protein
Quality of Life*
Randomized Controlled Trials as Topic
Receptors, Interleukin-1 / antagonists & inhibitors*
Recombinant Proteins / administration & dosage,  therapeutic use*
Sialoglycoproteins / administration & dosage,  therapeutic use*
Chemical
Reg. No./Substance:
0/Antirheumatic Agents; 0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Receptors, Interleukin-1; 0/Recombinant Proteins; 0/Sialoglycoproteins

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