Document Detail

Anaesthesia and angiotensin-converting enzyme inhibitors. The effect of enalapril on peri-operative cardiovascular stability.
MedLine Citation:
PMID:  2850747     Owner:  NLM     Status:  MEDLINE    
The effect of enalapril pretreatment on the haemodynamic response to tracheal intubation and surgical stimulation has been studied in 22 patients. Enalapril 5 mg given 4 hours before operation was associated with a significant reduction in the pressor response associated with intubation (p less than 0.05) and surgical stimulation (p less than 0.005) compared with control. Heart rate changes were similar in the two groups. The role of the renin-angiotensin system in relation to the pressor response to sympathetic stimulation is discussed and it is concluded that angiotensin-converting enzyme inhibitors may help improve peri-operative cardiovascular stability.
A P Yates; D N Hunter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anaesthesia     Volume:  43     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1989-02-17     Completed Date:  1989-02-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  935-8     Citation Subset:  AIM; IM    
Department of Anaesthesia, University College Hospital, London.
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MeSH Terms
Anesthesia, General*
Enalapril / therapeutic use*
Hemodynamics / drug effects
Hypertension / prevention & control*
Intubation, Intratracheal
Renin-Angiotensin System / drug effects
Surgical Procedures, Operative
Time Factors
Reg. No./Substance:

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